فصل و دراسة المركبات الفعالة من جذور الزنجبيل Zingiber officinalis في الأرانب السليمة و المصابة بداء السكر المستحدث بالألوكسان

الملخص EN

The study was included isolation of cold proteinous and non-proteinous extracts of Zingiber officinals roots.

The study also comprised the isolation and studying the proteinous compounds, using gel filtration technique which produced two compounds A (M.wt 108542 D) and B (M.wt 3247 D).

The proteinous and non-proteinous compounds were administrated interaperitioneally.

After one week from the treatment, the results were indicated that the proteinous precipitate and (B) proteinous compound at the doses (150,75) body weight which were caused a significant decrease (P < 0.05) in serum glucose (glu), total cholesterol (TC), total lipid, LDL-C levels , with an associated significant increase (P < 0.05) in serum HDL-C level, Glutathion (GSH) and superoxide dismutase (SOD) enzyme activity in liver, kidney and heart tissues, in normal and alloxan-induced diabetic rabbits.

Finally, It was suggested the proteinous compound B has antidiabetic and antioxidative stress effect in normal and diabetic rabbibts.