دراسة سريرية لهرمون الأديبونكتين و علاقته مع بعض المتغيرات لدى مرضى الأوعية الدموية القلبية في محافظة نينوى

الملخص EN

The research includes a clinical study of adiponectin hormone and its relation with cardiovascular diseases.

The normal value of adiponectin hormon level in human serum was found to be (9.79± 0.91 ug/ml) in control group for both sexes at age (35-70 year).

The study also showed a significant decrease in adiponectin hormone level (6.12 ±1.01 ug/ml)in serum of cardiovascular patients group for both sexes at (39 -75 year) in comparison to control.

The results also indicated a significant increase in the level of insulin hormone, glucose, insulin resistance (HOMA-IR), concentration of total cholesterol, triglyceride, low density lipoprotein -cholesterol, very low density lipoprotein -cholesterol, the risk factor ratio (total Cholesterol/ HDL), total lipid, malonaldehyde (MAD), the activity of Peroxidase, GOT and ALP in patients group.

While a significant decrease in concentration of high density lipoprotein - cholesterol, glutathione also the activity of glutathione -S- transfers, glutathione peroxidase, arylesterase and catalase in patients group was found in comparison to control.

The relationship between adiponectin hormone and some clinical variables were examined in control and patients.

The results showed that there were a significant positive correlation between adiponectin hormone and concenteration of high density lipoprotein - cholesterol (HDL- C), the activity of glutathione peroxidase and arylesterase in control group and patients.

The results also showed that there was a signifucant reverse correlation between adiponectin hormone and level of insulin hormone, glucose, insulin resistance (HOMA-IR), concenteration of total cholesterol, triglyceride, (total Cholesterol/ HDL), total lipid, malonaldehyde (MAD) and the activity of GOT and ALP in control group and patients.

It is concluded that the low level of the hormone adiponectin Index is a serious risk of cardiovascular disease and plays an important role in regulating the level of the hormone insulin, insulin resistance and its glucose, which refers to the relationship of diabetes.

It also shows a role in regulating the level of lipids and the relationship with oxidative stress processes.