تأثير المستخلص الكحولي للصابونين من بذور الحلبة على خصوبة ذكور الفئران البيض Albino Male Mice

الملخص EN

This experiment was designed to evaluate the effect of the saponin found in of the alcoholic extract fenugreek seeds on fertility in albino male mice through the follow-up of the physiological and histological changes which may be shown on some reproductive organs.

Animals were orally treated by daily 0.1 ml dose for 35 days by two different concentration doses (0.5 and 1.5 mg/ ml) of alcoholic extract of saponin from fenugreek seeds.

After 35 dn/s of treatment, blood and tissue samples were studied.

After examination and analysis the following results have been reached A significant ( P < 0.05 ) increases was found in mean of weight of epididymis , diameter of seminiferous tubules and epididymal tubes , thickness of endothelial cells of epididymis , and number of spermstogonia and leydig cells.

Concentration of sperm produced and levels of testosterone and interstitial cell stimulating hormone (ICSH ) were also significantly high in treated mice when compared with the control group.

No significant differences were found in mean body weight ,weight of testes , percentage of live sperm and level of follicle stimulating hormone ( fsh) in treated and control groups.

From the above mentioned outcomes we could conclude that saponin found in the fenugreek seeds may have a positive effect on some of the fertility factors in albino male mice.