مقارنة مستوى هرمون الارتروبيوتين لدى مرضى السكري من الرجال المصابين و غير المصابين باعتلال الكلي السكري

الملخص EN

Objective: It aims to estimate the level of Erythropoietin hormone at the serum of diabetic patient males with and without nephropathy.

Methodology: the present study was carried out in the center of Diabetes mellitus and Endocrinology in AL-Sader medical city for the period from October-2012 until March-2013.

The number of collected samples 73 urine and blood samples from the diabetic patients were divided in to two groups with and without nephropathy according the albumin and creatinine ratio in urine.

The statistical analysis, by using ( statistical package for social sciences) SPSS and t-test.

The least significant difference was calculated at the level P<0.05.

Results: the results were obtained, there were a significant increase (P<0.05) in the ratio of albumin to creatinine ratio in urine and the concentrations of glycosylated hemoglobin and urea, while the Erythropoietin and hemoglobin concentrations were revealed a significant decrease (P<0.05) at the patients with diabetic nephropathy when compared with patients in the other group.

In related with other parameters which included : iron ions, total iron binding capacity, ferritin and red blood corpuscles count were not showed any significant change during the present study.

Conclusion: the diabetes mellitus was affected on the kidney's physiological functions that led to a decrease in the Erythropoietin level at the serum of patients which caused an early anemia.

Recommendation: study the change in the cytokine level at the blood of diabetic patients to know the relation between there concentrations and diabetic nephropathy progression Keywords: Diabetes mellitus, Nephropathy, Erythropoietin, anemia, urea.