Baicalin’s Therapeutic Time Window of Neuroprotection during Transient Focal Cerebral Ischemia and Its Antioxidative Effects In Vitro and In Vivo
المؤلفون المشاركون
Guo, Shaoying
Qin, Jianguo
Zhong, Xiang-Gen
Cheng, Fafeng
Sun, Xiaoguang
Wang, Xueqian
Song, Wenting
Lu, Yi
Wang, Qingguo
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-06-25
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
We investigated the effects of baicalin on an ischemia-reperfusion-induced brain injury model in rats and its antioxidative activities in vitro and in vivo.
An ischemia-reperfusion injury of the brain via a middle cerebral artery occlusion (MCAO) was induced in rats.
Baicalin was injected at different time points (0, 2, 4, and 6 h) after the MCAO was induced.
Baicalin can improve neurological function and significantly decrease brain infarction within a time window of 4 h.
Moreover, baicalin was able to reduce cell apoptosis and had the strong antioxidative effect of reducing reactive oxygen species production and malondialdehyde generation.
In contrast, baicalin interfered with superoxide dismutase and nicotinamide adenine dinucleotide 2′-phosphate oxidase activities.
Moreover, baicalin also exhibited strong neuroprotective effects against H2O2-mediated injury and improved the SOD activity of neurons.
Furthermore, baicalin demonstrated good scavenging of hydroxyl radicals, superoxide anions, and DPPH radicals and exerted an additional effect of inhibiting xanthine oxidase.
Baicalin showed beneficial effects against MCAO-induced injury within a 4 h time window, and its antioxidative effects both in vitro and in vivo may partly elucidate its mechanism of action.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cheng, Fafeng& Lu, Yi& Zhong, Xiang-Gen& Song, Wenting& Wang, Xueqian& Sun, Xiaoguang…[et al.]. 2013. Baicalin’s Therapeutic Time Window of Neuroprotection during Transient Focal Cerebral Ischemia and Its Antioxidative Effects In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-447225
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cheng, Fafeng…[et al.]. Baicalin’s Therapeutic Time Window of Neuroprotection during Transient Focal Cerebral Ischemia and Its Antioxidative Effects In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-447225
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cheng, Fafeng& Lu, Yi& Zhong, Xiang-Gen& Song, Wenting& Wang, Xueqian& Sun, Xiaoguang…[et al.]. Baicalin’s Therapeutic Time Window of Neuroprotection during Transient Focal Cerebral Ischemia and Its Antioxidative Effects In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-447225
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-447225
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر