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The CYP2C19*1*2 Genotype Does Not Adequately Predict Clopidogrel Response in Healthy Malaysian Volunteers
المؤلفون المشاركون
Sheau Chin, Lim
Nasyuhana Sani, Yanti
Mohd Redhuan Shah Edwin, Nur Elyana Yazmin
Serebruany, Victor L.
Kah Hay, Yuen
Luen Hui, Lim
Teck Hwa, Goh
المصدر
Cardiology Research and Practice
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-01-31
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
The CYP2C19*2 allele may be associated with a reduced antiplatelet effect for clopidogrel.
Here, we assessed whether CYP2C19*2 alleles correlate with clopidogrel responsiveness following the administration of clopidogrel in healthy Malaysian volunteers.
Methods.
Ninety volunteers were genotyped for CYP2C19*2 and CYP2C19*3 alleles.
Forty-five of 90 volunteers were included in the clopidogrel response studies and triaged into three genotypes, namely, CYP2C19*1/*1 (n=17), CYP2C19*1/*2 (n=21), and CYP2C19*2/*2 (n=7).
All subjects received 300 mg of clopidogrel, and platelet reactivity was assessed after a four-hour loading utilizing the VerifyNow-P2Y12 assay.
Platelet activity was reported using P2Y12 reaction units (PRUs), and nonresponder status was prespecified at PRU ≥ 230.
Results.
Following clopidogrel intake, CYP2C19*2/*2 carriers had a significantly higher mean PRU compared to the CYP2C19*1/*2 and CYP2C19*1/*1 (291.0 ± 62.1 versus 232.5 ± 81.4 versus 147.4 ± 87.2 PRU, P<0.001) carriers.
Almost half of the participants (46.7%) were found to be nonresponders (3 were CYP2C19*1/*1, 11 were CYP2C19*1/*2, and 7 were CYP2C19*2/*2).
Conclusion.
In healthy Malaysian volunteers, CYP2C19*2 allele was associated with a decrease in platelet responsiveness to clopidogrel.
However, clopidogrel nonresponders can be found not only in the carriers of CYP2C19*2/*2, but also in the carriers of CYP2C19*1/*2 and CYP2C19*1/*1.
The present paper demonstrated that genotype information does not correlate with clopidogrel response, and genotyping may represent a less robust approach compared to platelet activity testing in guiding clopidogrel therapy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nasyuhana Sani, Yanti& Sheau Chin, Lim& Luen Hui, Lim& Mohd Redhuan Shah Edwin, Nur Elyana Yazmin& Teck Hwa, Goh& Serebruany, Victor L.…[et al.]. 2013. The CYP2C19*1*2 Genotype Does Not Adequately Predict Clopidogrel Response in Healthy Malaysian Volunteers. Cardiology Research and Practice،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-447939
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nasyuhana Sani, Yanti…[et al.]. The CYP2C19*1*2 Genotype Does Not Adequately Predict Clopidogrel Response in Healthy Malaysian Volunteers. Cardiology Research and Practice No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-447939
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nasyuhana Sani, Yanti& Sheau Chin, Lim& Luen Hui, Lim& Mohd Redhuan Shah Edwin, Nur Elyana Yazmin& Teck Hwa, Goh& Serebruany, Victor L.…[et al.]. The CYP2C19*1*2 Genotype Does Not Adequately Predict Clopidogrel Response in Healthy Malaysian Volunteers. Cardiology Research and Practice. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-447939
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-447939
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