A Risk-Scoring Model for the Prediction of Endometrial Cancer among Symptomatic Postmenopausal Women with Endometrial Thickness > 4 mm
المؤلفون المشاركون
Cerami, Lillo Bruno
Setti, Tiziano
Bergamini, Ezio
Mfuta, Kabala
Giannella, Luca
Boselli, Fausto
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-02
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objective.
To develop and test a risk-scoring model for the prediction of endometrial cancer among symptomatic postmenopausal women at risk of intrauterine malignancy.
Methods.
We prospectively studied 624 postmenopausal women with vaginal bleeding and endometrial thickness > 4 mm undergoing diagnostic hysteroscopy.
Patient characteristics and endometrial assessment of women with or without endometrial cancer were compared.
Then, a risk-scoring model, including the best predictors of endometrial cancer, was tested.
Univariate, multivariate, and ROC curve analysis were performed.
Finally, a split-sampling internal validation was also performed.
Results.
The best predictors of endometrial cancer were recurrent vaginal bleeding (odds ratio (OR)=2.96), the presence of hypertension (OR=2.01) endometrial thickness > 8 mm (OR=1.31), and age > 65 years (OR=1.11).
These variables were used to create a risk-scoring model (RHEA risk-model) for the prediction of intrauterine malignancy, with an area under the curve of 0.878 (95% CI 0.842 to 0.908; P<0.0001).
At the best cut-off value (score ≥ 4), sensitivity and specificity were 87.5% and 80.1%, respectively.
Conclusion.
Among symptomatic postmenopausal women with endometrial thickness > 4 mm, a risk-scoring model including patient characteristics and endometrial thickness showed a moderate diagnostic accuracy in discriminating women with or without endometrial cancer.
Based on this model, a decision algorithm was developed for the management of such a population.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Giannella, Luca& Mfuta, Kabala& Setti, Tiziano& Cerami, Lillo Bruno& Bergamini, Ezio& Boselli, Fausto. 2014. A Risk-Scoring Model for the Prediction of Endometrial Cancer among Symptomatic Postmenopausal Women with Endometrial Thickness > 4 mm. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-448093
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Giannella, Luca…[et al.]. A Risk-Scoring Model for the Prediction of Endometrial Cancer among Symptomatic Postmenopausal Women with Endometrial Thickness > 4 mm. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-448093
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Giannella, Luca& Mfuta, Kabala& Setti, Tiziano& Cerami, Lillo Bruno& Bergamini, Ezio& Boselli, Fausto. A Risk-Scoring Model for the Prediction of Endometrial Cancer among Symptomatic Postmenopausal Women with Endometrial Thickness > 4 mm. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-448093
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-448093
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر