Unsupervised Two-Way Clustering of Metagenomic Sequences

المؤلفون المشاركون

Acharya, Raj
Prabhakara, Shruthi

المصدر

Journal of Biomedicine and Biotechnology

العدد

المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-11، 11ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2012-04-05

دولة النشر

مصر

عدد الصفحات

11

التخصصات الرئيسية

الطب البشري

الملخص EN

A major challenge facing metagenomics is the development of tools for the characterization of functional and taxonomic content of vast amounts of short metagenome reads.

The efficacy of clustering methods depends on the number of reads in the dataset, the read length and relative abundances of source genomes in the microbial community.

In this paper, we formulate an unsupervised naive Bayes multispecies, multidimensional mixture model for reads from a metagenome.

We use the proposed model to cluster metagenomic reads by their species of origin and to characterize the abundance of each species.

We model the distribution of word counts along a genome as a Gaussian for shorter, frequent words and as a Poisson for longer words that are rare.

We employ either a mixture of Gaussians or mixture of Poissons to model reads within each bin.

Further, we handle the high-dimensionality and sparsity associated with the data, by grouping the set of words comprising the reads, resulting in a two-way mixture model.

Finally, we demonstrate the accuracy and applicability of this method on simulated and real metagenomes.

Our method can accurately cluster reads as short as 100 bps and is robust to varying abundances, divergences and read lengths.Erratum to “Unsupervised Two-Way Clustering of Metagenomic Sequences”dx.doi.org/10.1155/2012/795820

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Prabhakara, Shruthi& Acharya, Raj. 2012. Unsupervised Two-Way Clustering of Metagenomic Sequences. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-450070

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Prabhakara, Shruthi& Acharya, Raj. Unsupervised Two-Way Clustering of Metagenomic Sequences. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-450070

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Prabhakara, Shruthi& Acharya, Raj. Unsupervised Two-Way Clustering of Metagenomic Sequences. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-450070

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-450070