α-Enolase, a Multifunctional Protein : Its Role on Pathophysiological Situations
المؤلفون المشاركون
García-Melero, Ana
Roig-Borrellas, Anna
Díaz-Ramos, Àngels
López-Alemany, Roser
المصدر
Journal of Biomedicine and Biotechnology
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-10-14
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
α-Enolase is a key glycolytic enzyme in the cytoplasm of prokaryotic and eukaryotic cells and is considered a multifunctional protein.
α-enolase is expressed on the surface of several cell types, where it acts as a plasminogen receptor, concentrating proteolytic plasmin activity on the cell surface.
In addition to glycolytic enzyme and plasminogen receptor functions, α-Enolase appears to have other cellular functions and subcellular localizations that are distinct from its well-established function in glycolysis.
Furthermore, differential expression of α-enolase has been related to several pathologies, such as cancer, Alzheimer's disease, and rheumatoid arthritis, among others.
We have identified α-enolase as a plasminogen receptor in several cell types.
In particular, we have analyzed its role in myogenesis, as an example of extracellular remodelling process.
We have shown that α-enolase is expressed on the cell surface of differentiating myocytes, and that inhibitors of α-enolase/plasminogen binding block myogenic fusion in vitro and skeletal muscle regeneration in mice.
α-Enolase could be considered as a marker of pathological stress in a high number of diseases, performing several of its multiple functions, mainly as plasminogen receptor.
This paper is focused on the multiple roles of the α-enolase/plasminogen axis, related to several pathologies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Díaz-Ramos, Àngels& Roig-Borrellas, Anna& García-Melero, Ana& López-Alemany, Roser. 2012. α-Enolase, a Multifunctional Protein : Its Role on Pathophysiological Situations. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-450300
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Díaz-Ramos, Àngels…[et al.]. α-Enolase, a Multifunctional Protein : Its Role on Pathophysiological Situations. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-450300
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Díaz-Ramos, Àngels& Roig-Borrellas, Anna& García-Melero, Ana& López-Alemany, Roser. α-Enolase, a Multifunctional Protein : Its Role on Pathophysiological Situations. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-450300
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-450300
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر