![](/images/graphics-bg.png)
IL-18 Serum Level in Adult Onset Still’s Disease : A Marker of Disease Activity
المؤلفون المشاركون
Valesini, Guido
Colafrancesco, Serena
Priori, Roberta
Picarelli, Giovanna
Pendolino, Monica
Alessandri, Cristiano
Perricone, Carlo
المصدر
International Journal of Inflammation
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-06-18
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Introduction.
Immunological factors seem to play a pivotal role in Adult Onset Still's Disease (AOSD).
Among all, IL-18 cytokine is overexpressed and drives the inflammatory process.
Objective.
We aimed to investigate the levels of IL-18 in sera of Italian patients with AOSD and to assess its possible role as a marker of disease activity.
Methods.
IL-18 serum levels were determined by ELISA in 26 Italian patients with AOSD.
Disease activity was assessed using Pouchot’s criteria.
As controls, 21 patients with Rheumatoid Arthritis (RA), 21 patients with Sjogren's Syndrome (SS), 20 patients with Systemic Lupus Erythematosus (SLE), and 21 healthy subjects (normal human sera, NHS) were evaluated.
Results.
IL-18 serum levels were significantly higher in patients with active AOSD than in non-active (P=0.001) and control groups (RA P=0.0070, SS P=0.0029, SLE P=0.0032, NHS P=0.0004).
A significant correlation between IL-18 serum levels and disease activity (P<0.0001), and laboratory parameters as ferritin (P=0.0127) and C-reactive protein (P=0.0032) was demonstrated.
Conclusions.
Higher levels of IL-18 are detected in active AODS patients and correlate with disease activity and inflammatory laboratory features.
ROC-AUC analysis of the serum concentration of IL-18 suggests that it can be considered a diagnostic marker of AOSD.
This paper supports the targeting of this cytokine as a possible therapeutic option in AOSD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Colafrancesco, Serena& Priori, Roberta& Alessandri, Cristiano& Perricone, Carlo& Pendolino, Monica& Picarelli, Giovanna…[et al.]. 2012. IL-18 Serum Level in Adult Onset Still’s Disease : A Marker of Disease Activity. International Journal of Inflammation،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-450318
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Colafrancesco, Serena…[et al.]. IL-18 Serum Level in Adult Onset Still’s Disease : A Marker of Disease Activity. International Journal of Inflammation No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-450318
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Colafrancesco, Serena& Priori, Roberta& Alessandri, Cristiano& Perricone, Carlo& Pendolino, Monica& Picarelli, Giovanna…[et al.]. IL-18 Serum Level in Adult Onset Still’s Disease : A Marker of Disease Activity. International Journal of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-450318
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-450318
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)