Thirty Years with HIV Infection—Nonprogression Is Still Puzzling : Lessons to Be Learned from Controllers and Long-Term Nonprogressors
المؤلفون المشاركون
Hartling, Hans J.
Nielsen, Susanne Dam
Gerstoft, Jan
Gaardbo, Julie C.
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-05-27
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
In the early days of the HIV epidemic, it was observed that a minority of the infected patients did not progress to AIDS or death and maintained stable CD4+ cell counts.
As the technique for measuring viral load became available it was evident that some of these nonprogressors in addition to preserved CD4+ cell counts had very low or even undetectable viral replication.
They were therefore termed controllers, while those with viral replication were termed long-term nonprogressors (LTNPs).
Genetics and virology play a role in nonprogression, but does not provide a full explanation.
Therefore, host differences in the immunological response have been proposed.
Moreover, the immunological response can be divided into an immune homeostasis resistant to HIV and an immune response leading to viral control.
Thus, non-progression in LTNP and controllers may be due to different immunological mechanisms.
Understanding the lack of disease progression and the different interactions between HIV and the immune system could ideally teach us how to develop a functional cure for HIV infection.
Here we review immunological features of controllers and LTNP, highlighting differences and clinical implications.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gaardbo, Julie C.& Hartling, Hans J.& Gerstoft, Jan& Nielsen, Susanne Dam. 2012. Thirty Years with HIV Infection—Nonprogression Is Still Puzzling : Lessons to Be Learned from Controllers and Long-Term Nonprogressors. AIDS Research and Treatment،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-450753
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gaardbo, Julie C.…[et al.]. Thirty Years with HIV Infection—Nonprogression Is Still Puzzling : Lessons to Be Learned from Controllers and Long-Term Nonprogressors. AIDS Research and Treatment No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-450753
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gaardbo, Julie C.& Hartling, Hans J.& Gerstoft, Jan& Nielsen, Susanne Dam. Thirty Years with HIV Infection—Nonprogression Is Still Puzzling : Lessons to Be Learned from Controllers and Long-Term Nonprogressors. AIDS Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-450753
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-450753
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر