Coordinated Regulation of PPARγ Expression and Activity through Control of Chromatin Structure in Adipogenesis and Obesity

المصدر

PPAR Research

العدد

المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-9، 9ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2012-09-06

دولة النشر

مصر

عدد الصفحات

9

التخصصات الرئيسية

العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأحياء

الملخص EN

The nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ) is required for differentiation and function of mature adipocytes.

Its expression is induced during adipogenesis where it plays a key role in establishing the transcriptome of terminally differentiated white fat cells.

Here, we review findings indicating that PPARγ expression and activity are intricately regulated through control of chromatin structure.

Hierarchical and combinatorial activation of transcription factors, noncoding RNAs, and chromatin remodelers allows for temporally controlled expression of PPARγ and its target genes through sequential chromatin remodelling.

In obesity, these regulatory pathways may be altered and lead to modified PPARγ activity.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

2012. Coordinated Regulation of PPARγ Expression and Activity through Control of Chromatin Structure in Adipogenesis and Obesity. PPAR Research،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-450987

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Coordinated Regulation of PPARγ Expression and Activity through Control of Chromatin Structure in Adipogenesis and Obesity. PPAR Research No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-450987

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Coordinated Regulation of PPARγ Expression and Activity through Control of Chromatin Structure in Adipogenesis and Obesity. PPAR Research. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-450987

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-450987