High Expression of Complement Component 5 (C5) at Tumor Site Associates with Superior Survival in Ewing's Sarcoma Family of Tumour Patients
المؤلفون المشاركون
Picci, Piero
Myllykangas, Samuel
Knuutila, Sakari
Manara, Cristina
Savola, Suvi
Vakkila, Jukka
Scotlandi, Katia
Klami, Arto
المصدر
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-10-02
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
Unlike in most adult-onset cancers, an association between typical paediatric neoplasms and inflammatory triggers is rare.
We studied whether immune system-related genes are activated and have prognostic significance in Ewing's sarcoma family of tumors (ESFTs).
Method.
Data analysis was performed on gene expression profiles of 44 ESFT patients, 11 ESFT cell lines, and 18 normal skeletal muscle samples.
Differential expression of 238 inflammation and 299 macrophage-related genes was analysed by t-test, and survival analysis was performed according to gene expression.
Results.
Inflammatory genes are activated in ESFT patient samples, as 38 of 238 (16%) inflammatory genes were upregulated (P<0.001) when compared to cell lines.
This inflammatory gene activation was characterized by significant enrichment of macrophage-related gene expression with 58 of 299 (19%) of genes upregulated (P<0.001).
High expression of complement component 5 (C5) correlated with better event-free (P=0.01) and overall survival (P=0.004) in a dose-dependent manner.
C5 and its receptor C5aR1 expression was verified at protein level by immunohistochemistry on an independent ESFT tumour tissue microarray.
Conclusion.
Immune system-related gene activation is observed in ESFT patient samples, and prognostically significant inflammatory genes (C5, JAK1, and IL8) for ESFT were identified.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Savola, Suvi& Klami, Arto& Myllykangas, Samuel& Manara, Cristina& Scotlandi, Katia& Picci, Piero…[et al.]. 2011. High Expression of Complement Component 5 (C5) at Tumor Site Associates with Superior Survival in Ewing's Sarcoma Family of Tumour Patients. ISRN Oncology،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-451346
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Savola, Suvi…[et al.]. High Expression of Complement Component 5 (C5) at Tumor Site Associates with Superior Survival in Ewing's Sarcoma Family of Tumour Patients. ISRN Oncology No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-451346
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Savola, Suvi& Klami, Arto& Myllykangas, Samuel& Manara, Cristina& Scotlandi, Katia& Picci, Piero…[et al.]. High Expression of Complement Component 5 (C5) at Tumor Site Associates with Superior Survival in Ewing's Sarcoma Family of Tumour Patients. ISRN Oncology. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-451346
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-451346
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر