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Stress and Its Effects on Glucose Metabolism and 11β-HSD Activities in Rats Fed on a Combination of High-Fat and High-Sucrose Diet with Glycyrrhizic Acid
المؤلفون المشاركون
Fernando, Hamish Alexander
Chin, Hsien-Fei
Ton, So Ha
Abdul Kadir, Khalid
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-18، 18ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-03-18
دولة النشر
مصر
عدد الصفحات
18
التخصصات الرئيسية
الملخص EN
Chronic stress has been shown to have a strong link towards metabolic syndrome (MetS).
Glycyrrhizic acid (GA) meanwhile has been shown to improve MetS symptoms caused by an unhealthy diet by inhibiting 11β-HSD 1.
This experiment aimed to determine the effects of continuous, moderate-intensity stress on rats with and without GA intake on systolic blood pressure (SBP) across a 28-day period, as well as glucose metabolism, and 11β-HSD 1 and 2 activities at the end of the 28-day period.
Adaptation to the stressor (as shown by SBP) resulted in no significant defects in glucose metabolism by the end of the experimental duration.
However, a weakly significant increase in renal 11β-HSD 1 and a significant increase in subcutaneous adipose tissue 11β-HSD 1 activities were observed.
GA intake did not elicit any significant benefit in glucose metabolism, indicating that the stress response may block its effects.
However, GA-induced improvements in 11β-HSD activities in certain tissues were observed, although it is uncertain if these effects are manifested after adaptation due to the withdrawal of the stress response.
Hence the ability of GA to improve stress-induced disturbances in the absence of adaptation needs to be investigated further.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fernando, Hamish Alexander& Chin, Hsien-Fei& Ton, So Ha& Abdul Kadir, Khalid. 2013. Stress and Its Effects on Glucose Metabolism and 11β-HSD Activities in Rats Fed on a Combination of High-Fat and High-Sucrose Diet with Glycyrrhizic Acid. Journal of Diabetes Research،Vol. 2013, no. 2013, pp.1-18.
https://search.emarefa.net/detail/BIM-453152
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fernando, Hamish Alexander…[et al.]. Stress and Its Effects on Glucose Metabolism and 11β-HSD Activities in Rats Fed on a Combination of High-Fat and High-Sucrose Diet with Glycyrrhizic Acid. Journal of Diabetes Research No. 2013 (2013), pp.1-18.
https://search.emarefa.net/detail/BIM-453152
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fernando, Hamish Alexander& Chin, Hsien-Fei& Ton, So Ha& Abdul Kadir, Khalid. Stress and Its Effects on Glucose Metabolism and 11β-HSD Activities in Rats Fed on a Combination of High-Fat and High-Sucrose Diet with Glycyrrhizic Acid. Journal of Diabetes Research. 2013. Vol. 2013, no. 2013, pp.1-18.
https://search.emarefa.net/detail/BIM-453152
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-453152
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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