Bone-Targeted Therapies in Metastatic Castration-Resistant Prostate Cancer : Evolving Paradigms
المؤلفون المشاركون
Aragon-Ching, Jeanny B.
Patel, Nihar
Freeman, Ashley
El-Amm, Joelle
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-08-28
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Majority of patients with metastatic castrate resistant prostate cancer (mCRPC) develop bone metastases which results in significant morbidity and mortality as a result of skeletal-related events (SREs).
Several bone-targeted agents are either in clinical use or in development for prevention of SREs.
Bisphosphonates were the first class of drugs investigated for prevention of SREs and zoledronic acid is the only bisphosphonate that is FDA-approved for this indication.
Another bone-targeted agent is denosumab which is a fully humanized monoclonal antibody that binds to the RANK-L thereby inhibiting RANK-L mediated bone resorption.
While several radiopharmaceuticals were approved for pain palliation in mCRPC including strontium and samarium, alpharadin is the first radiopharmaceutical to show significant overall survival benefit.
Contemporary therapeutic options including enzalutamide and abiraterone have effects on pain palliation and SREs as well.
Other novel bone-targeted agents are currently in development, including the receptor tyrosine kinase inhibitors cabozantinib and dasatinib.
Emerging therapeutics in mCRPC has resulted in great strides in preventing one of the most significant sources of complications of bone metastases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
El-Amm, Joelle& Freeman, Ashley& Patel, Nihar& Aragon-Ching, Jeanny B.. 2013. Bone-Targeted Therapies in Metastatic Castration-Resistant Prostate Cancer : Evolving Paradigms. Prostate Cancer،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-454863
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
El-Amm, Joelle…[et al.]. Bone-Targeted Therapies in Metastatic Castration-Resistant Prostate Cancer : Evolving Paradigms. Prostate Cancer No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-454863
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
El-Amm, Joelle& Freeman, Ashley& Patel, Nihar& Aragon-Ching, Jeanny B.. Bone-Targeted Therapies in Metastatic Castration-Resistant Prostate Cancer : Evolving Paradigms. Prostate Cancer. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-454863
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-454863
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر