Strain Diversity of Mycobacterium tuberculosis Isolates from Pulmonary Tuberculosis Patients in Afar Pastoral Region of Ethiopia
المؤلفون المشاركون
Bjune, Gunnar
Abebe, Fekadu
Ameni, Gobena
Rastogi, Nalin
Belay, Mulugeta
Couvin, David
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-06
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Data on genotypic diversity of Mycobacterium tuberculosis complex (MTBC) is important to understand its epidemiology, human adaptation, clinical phenotypes, and drug resistance.
This study aimed to characterize MTBC clinical isolates circulating in a predominantly pastoralist area in Ethiopia, a country where tuberculosis is the second leading cause of mortality.
Culture of sputum samples collected from a total of 325 pulmonary TB suspects was done to isolate MTBC.
Spoligotyping was used to characterize 105 isolates from culture positive slopes and the result was compared with an international database.
Forty-four spoligotype patterns were observed to correspond to 35 shared-types (SITs) containing 96 isolates and 9 orphan patterns; 27 SITs containing 83 isolates matched a preexisting shared-type in the database, whereas 8 SITs (n=13 isolates) were newly created.
A total of 19 SITs containing 80 isolates were clustered within this study (overall clustering of 76.19%).
Three dominant lineages (T, CAS, and Manu) accounted for 76.19% of the isolates.
SIT149/T3-ETH was one of the two most dominant sublineages.
Unlike previous reports, we show that Manu lineage strains not only constitute a dominant lineage, but are also associated with HIV infection in Afar region of Ethiopia.
The high level of clustering suggests the presence of recent transmission that should be further studied using additional genotyping markers.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Belay, Mulugeta& Ameni, Gobena& Bjune, Gunnar& Couvin, David& Rastogi, Nalin& Abebe, Fekadu. 2014. Strain Diversity of Mycobacterium tuberculosis Isolates from Pulmonary Tuberculosis Patients in Afar Pastoral Region of Ethiopia. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-456357
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Belay, Mulugeta…[et al.]. Strain Diversity of Mycobacterium tuberculosis Isolates from Pulmonary Tuberculosis Patients in Afar Pastoral Region of Ethiopia. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-456357
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Belay, Mulugeta& Ameni, Gobena& Bjune, Gunnar& Couvin, David& Rastogi, Nalin& Abebe, Fekadu. Strain Diversity of Mycobacterium tuberculosis Isolates from Pulmonary Tuberculosis Patients in Afar Pastoral Region of Ethiopia. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-456357
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-456357
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر