Polymorphism of μ-Opioid Receptor Gene (OPRM1 : c.118A>G) Might Not Protect against or Enhance Morphine-Induced Nausea or Vomiting
المؤلفون المشاركون
Lin, Chen-Jung
Yang, Hong-Jyh
Chien, Kuo-Liong
Chen, Li-Kuei
Chen, Shiou-Sheng
Huang, Chi-Hsiang
Fan, Shou-Zen
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-02-04
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
A cohort, double blind, and randomized study was conducted to investigate the effect of a single nucleotide polymorphism of the μ-opioid receptor at nucleotide position 118 (OPRM1:c.118A>G) on the association with the most common side effects (nausea or vomiting) induced by intravenous patient control analgesia (IVPCA) with morphine, including incidence and severity analysis.
A total of 129 Taiwanese women undergoing gynecology surgery received IVPCA with pure morphine for postoperative pain relief.
Blood samples were collected and sequenced with high resolution melting analysis to detect three different genotypes of OPRM1 (AA, AG, and GG).
All candidates 24 h postoperatively will be interviewed to record the clinical phenotype with subjective complaints and objective observations.
The genotyping after laboratory analysis showed that 56 women (43.4%) were AA, 57 (44.2%) were AG, and 16 (12.4%) were GG.
The distribution of genotype did not violate Hardy-Weinberg equilibrium test.
There was no significant difference neither between the severity and incidence of IVPCA morphine-induced side effects and genotype nor between the association between morphine consumption versus genotype.
However, there was significant difference of the relation between morphine consumption and the severity and incidence of IVPCA morphine-induced nausea and vomiting.
The genetic analysis for the severity and incidence of IVPCA morphine-induced nausea or vomiting showed no association between phenotype and genotype.
It might imply that OPRM1:c.118A>G does not protect against IVPCA morphine-induced nausea or vomiting.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Li-Kuei& Chen, Shiou-Sheng& Huang, Chi-Hsiang& Yang, Hong-Jyh& Lin, Chen-Jung& Chien, Kuo-Liong…[et al.]. 2013. Polymorphism of μ-Opioid Receptor Gene (OPRM1 : c.118A>G) Might Not Protect against or Enhance Morphine-Induced Nausea or Vomiting. Pain Research and Treatment،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-458166
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Li-Kuei…[et al.]. Polymorphism of μ-Opioid Receptor Gene (OPRM1 : c.118A>G) Might Not Protect against or Enhance Morphine-Induced Nausea or Vomiting. Pain Research and Treatment No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-458166
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Li-Kuei& Chen, Shiou-Sheng& Huang, Chi-Hsiang& Yang, Hong-Jyh& Lin, Chen-Jung& Chien, Kuo-Liong…[et al.]. Polymorphism of μ-Opioid Receptor Gene (OPRM1 : c.118A>G) Might Not Protect against or Enhance Morphine-Induced Nausea or Vomiting. Pain Research and Treatment. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-458166
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-458166
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر