β-Thalassemia Intermedia in Northern Iraq : A Single Center Experience
المؤلفون المشاركون
Mohammad, Ameen M.
Omer, Sharaza Q.
al-Allawi, Nasir A. S.
Jalal, Sana D.
Markous, Raji S. D.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-02-27
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
To investigate the molecular basis of β-thalassemia intermedia in Northern Iraq and evaluate its management practices, a total of 74 patients from 51 families were enrolled.
The patients were clinically and hematologically reevaluated, and had their β-thalassemia mutations characterized, as well as the number of α-globin genes and Xmn I Gγ −158 (C>T) polymorphism studied.
Out of 14 β-thalassemia mutations identified, the four most common were IVS-I-6 (T>C) [33.3%], IVS-II-I (G>A) [21.1%], codon 82/83(−G) [10.1%], and codon 8 (−AA) [8.1%].
The most common contributing factors to the less severe phenotype of thalassemia intermedia were found to be the inheritance of mild β-thalassemia alleles and the Xmn I polymorphism, while concomitant α-thalassemia had a limited role.
Several complications were documented including: pulmonary hypertension in 20.4%, diabetes mellitus in 1.4%, hypothyroidism in 2.9%, and heart failure in 2.7%, while no documented cases of venous thrombosis were found.
Compared to their counterparts in several Mediterranean countries, it appears that our patients were much less frequently transfused and had a lower proportion of patients who were splenectomized, on iron chelation, or hydroxycarbamide therapy.
Such practices require further scrutiny to ensure that a better level of care is provided and that growth retardation, skeletal changes, and other complications are prevented or reduced.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Allawi, Nasir A. S.& Jalal, Sana D.& Mohammad, Ameen M.& Omer, Sharaza Q.& Markous, Raji S. D.. 2014. β-Thalassemia Intermedia in Northern Iraq : A Single Center Experience. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-458492
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Allawi, Nasir A. S.…[et al.]. β-Thalassemia Intermedia in Northern Iraq : A Single Center Experience. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-458492
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Allawi, Nasir A. S.& Jalal, Sana D.& Mohammad, Ameen M.& Omer, Sharaza Q.& Markous, Raji S. D.. β-Thalassemia Intermedia in Northern Iraq : A Single Center Experience. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-458492
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-458492
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر