Clinical Benefit of Second-Line Palliative Chemotherapy in Advanced Soft-Tissue Sarcoma
المؤلفون المشاركون
Judson, Ian R.
Minchom, Anna
al-Muderis, Omar
Karavasilis, Vasilios
Fisher, Cyril
Jones, Robin L.
Ashley, Sue
Scurr, Michelle
المصدر
العدد
المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-05-20
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
This paper aimed to assess the utility of second-line chemotherapy in patients with advanced soft-tissue sarcoma.
Materials and Methods.
A retrospective search of a prospectively maintained database identified patients treated between 1991 and 2005.
Patients with gastrointestinal stromal tumours, small round cell tumours, and Ewing's sarcoma were excluded.
Response was assessed using WHO and RECIST.
Patients who achieved stable disease for 6 months or more were classified as having disease control.
Results.
Three hundred and seventy-nine patients received second-line chemotherapy.
Eighty-six (22.7%) achieved disease control.
Median duration of response was 11 months (95% CI: 9–13).
On multivariate analysis, pathological subtype, absence of lung metastases, and the use of combination chemotherapy were independent predictors of disease control.
Twenty-eight (16.1%) patients who failed to respond to first-line therapy achieved disease control.
Eight (2.1%) patients had sufficient downstaging to enable complete surgical resection.
Progression-free survival was 23% at 6 months.
Median overall survival was 8 months (95% CI: 7–10 months).
On multivariate analysis, synovial histology and absence of lung metastases were associated with improved survival.
Conclusion.
Second-line chemotherapy can provide clinical benefit in over 20% of soft-tissue sarcoma patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Minchom, Anna& Jones, Robin L.& Fisher, Cyril& al-Muderis, Omar& Ashley, Sue& Scurr, Michelle…[et al.]. 2010. Clinical Benefit of Second-Line Palliative Chemotherapy in Advanced Soft-Tissue Sarcoma. Sarcoma،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-458643
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Minchom, Anna…[et al.]. Clinical Benefit of Second-Line Palliative Chemotherapy in Advanced Soft-Tissue Sarcoma. Sarcoma No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-458643
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Minchom, Anna& Jones, Robin L.& Fisher, Cyril& al-Muderis, Omar& Ashley, Sue& Scurr, Michelle…[et al.]. Clinical Benefit of Second-Line Palliative Chemotherapy in Advanced Soft-Tissue Sarcoma. Sarcoma. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-458643
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-458643
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر