Development of 68Ga-Glycopeptide as an Imaging Probe for Tumor Angiogenesis
المؤلفون المشاركون
Yu, Dong-Fang
Tzen, Kai-Yuan
Tsao, Ning
Wang, Chau-Hui
Yang, David J.
Her, Li-Jane
Chen, Jing-Yi
المصدر
Journal of Biomedicine and Biotechnology
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-04-07
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Objective.
This study was aimed to study tissue distribution and tumor imaging potential of 68Ga-glycopeptide (GP) in tumor-bearing rodents by PET.
Methods.
GP was synthesized by conjugating glutamate peptide and chitosan.
GP was labeled with 68Ga chloride for in vitro and in vivo studies.
Computer outlined region of interest (counts per pixel) of the tumor and muscle (at the symmetric site) was used to determine tumor-to-muscle count density ratios.
To ascertain the feasibility of 68Ga-GP in tumor imaging in large animals, PET/CT imaging of 68Ga-GP and 18F-FDG were conducted in New Zealand white rabbits bearing VX2 tumors.
Standard uptake value of tumors were determined by PET up to 45 min.
To determine blood clearance and half-life of 68Ga-GP, blood samples were collected from 10 seconds to 20 min.
Results.
Radiochemical purity of 68Ga-GP determined by instant thin-layer chromatography was >95%.
Tumor uptake values (SUV) for 68Ga-GP and 18F-FDG in New Zealand white rabbits bearing VX2 tumors were 3.25 versus 7.04.
PET images in tumor-bearing rats and rabbits confirmed that 68Ga-GP could assess tumor uptake.
From blood clearance curve, the half-life of 68Ga-GP was 1.84 hr.
Conclusion Our data indicate that it is feasible to use 68Ga-GP to assess tumor angiogenesis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tsao, Ning& Wang, Chau-Hui& Her, Li-Jane& Tzen, Kai-Yuan& Chen, Jing-Yi& Yu, Dong-Fang…[et al.]. 2011. Development of 68Ga-Glycopeptide as an Imaging Probe for Tumor Angiogenesis. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-458804
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tsao, Ning…[et al.]. Development of 68Ga-Glycopeptide as an Imaging Probe for Tumor Angiogenesis. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-458804
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tsao, Ning& Wang, Chau-Hui& Her, Li-Jane& Tzen, Kai-Yuan& Chen, Jing-Yi& Yu, Dong-Fang…[et al.]. Development of 68Ga-Glycopeptide as an Imaging Probe for Tumor Angiogenesis. Journal of Biomedicine and Biotechnology. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-458804
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-458804
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر