The Apolipoprotein C-I Content of Very-Low-Density Lipoproteins Is Associated with Fasting Triglycerides, Postprandial Lipemia, and Carotid Atherosclerosis
المؤلفون المشاركون
Hansen, John-Bjarne
Deguchi, Hiroshi
Björkegren, Johan
Notø, Ann-Trude With
Mathiesen, Ellisiv B.
Fernández, José A.
المصدر
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-07-06
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
Experimental studies in animals suggest that apolipoprotein (apo) C-I is an important regulator of triglycerides in fasting and postprandial conditions and associated with carotid atherosclerosis.
Methods.
A cross-sectional study was conducted with 81 subjects, aged 56–80 years recruited from a population health survey.
The participants underwent a fat tolerance test (1 g fat per Kg body weight) and carotid atherosclerosis was determined by ultrasound examination.
VLDL particles, Sf 20–400, were isolated and their lipid composition and apoC-I content determined.
Results.
The carotid plaque area increased linearly with the number of apoC-I molecules per VLDL particles (P=0.048) under fasting conditions.
Fasting triglycerides increased across tertiles of apoC-I per VLDL particle in analyses adjusted for apoC-II and -C-III, apoE genotype and traditional cardiovascular risk factors (P=0.011).
The relation between apoC-I in VLDL and serum triglycerides was conveyed by triglyceride enrichment of VLDL particles (P for trend <0.001.
The amount of apoC-I molecules per VLDL was correlated with the total (r=0.41, P<0.0001) and incremental (r=0.35, P<0.001) area under the postprandial triglyceride curve.
Conclusions.
Our findings support the concept that the content of apoC-I per VLDL particle is an important regulator of triglyceride metabolism in the fasting and postprandial state and associated with carotid athrosclerosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hansen, John-Bjarne& Fernández, José A.& Notø, Ann-Trude With& Deguchi, Hiroshi& Björkegren, Johan& Mathiesen, Ellisiv B.. 2011. The Apolipoprotein C-I Content of Very-Low-Density Lipoproteins Is Associated with Fasting Triglycerides, Postprandial Lipemia, and Carotid Atherosclerosis. Journal of Lipids،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-459170
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hansen, John-Bjarne…[et al.]. The Apolipoprotein C-I Content of Very-Low-Density Lipoproteins Is Associated with Fasting Triglycerides, Postprandial Lipemia, and Carotid Atherosclerosis. Journal of Lipids No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-459170
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hansen, John-Bjarne& Fernández, José A.& Notø, Ann-Trude With& Deguchi, Hiroshi& Björkegren, Johan& Mathiesen, Ellisiv B.. The Apolipoprotein C-I Content of Very-Low-Density Lipoproteins Is Associated with Fasting Triglycerides, Postprandial Lipemia, and Carotid Atherosclerosis. Journal of Lipids. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-459170
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-459170
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر