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Rapid Decrease of CD16 (FcγRIII) Expression on Heat-Shocked Neutrophils and Their Recognition by Macrophages
المؤلفون المشاركون
Bzowska, Małgorzata
Skalniak, Anna
Guzik, Krzysztof
Hamczyk, Magda
المصدر
Journal of Biomedicine and Biotechnology
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-04-27
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Accumulation of neutrophils in the site of inflammation is a typical mechanism of innate immunity.
The accumulated neutrophils are exposed to stressogenic factors usually associated with inflammation.
Here, we studied response of human peripheral blood neutrophils subjected to short, febrile-range heat stress.
We show that 90 min heat stress slowed down the spontaneous apoptosis of neutrophils.
In the absence of typical markers of apoptosis the heat-shocked neutrophils induced antiinflammatory effect in human monocyte-derived macrophages (hMDMs), yet without being engulfed.
Importantly, the expression of FcγRIII (CD16) was sharply reduced.
Surprisingly, concentration of the soluble CD16 did not change in heat-shocked neutrophil supernates indicating that the reduction of the cell surface CD16 was achieved mainly by inhibition of fresh CD16 delivery.
Inhibitors of 90 kDa heat shock protein (HSP90), a molecular chaperone found in membrane platforms together with CD16 and CD11b, significantly increased the observed effects caused by heat shock.
The presented data suggest a novel systemic aspect of increased temperature which relies on immediate modification by heat of a neutrophil molecular pattern.
This effect precedes cell death and may be beneficial in the initial phase of inflammation providing a nonphlogistic signal to macrophages before it comes from apoptotic cells.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bzowska, Małgorzata& Hamczyk, Magda& Skalniak, Anna& Guzik, Krzysztof. 2011. Rapid Decrease of CD16 (FcγRIII) Expression on Heat-Shocked Neutrophils and Their Recognition by Macrophages. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-460307
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bzowska, Małgorzata…[et al.]. Rapid Decrease of CD16 (FcγRIII) Expression on Heat-Shocked Neutrophils and Their Recognition by Macrophages. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-14.
https://search.emarefa.net/detail/BIM-460307
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bzowska, Małgorzata& Hamczyk, Magda& Skalniak, Anna& Guzik, Krzysztof. Rapid Decrease of CD16 (FcγRIII) Expression on Heat-Shocked Neutrophils and Their Recognition by Macrophages. Journal of Biomedicine and Biotechnology. 2011. Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-460307
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-460307
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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