Propolis Induces ChondroitinDermatan Sulphate and Hyaluronic Acid Accumulation in the Skin of Burned Wound

المؤلفون المشاركون

Kozma, Ewa M.
Stojko, Jerzy
Klimek, Katarzyna
Olczyk, Pawel
Winsz-Szczotka, Katarzyna
Komosinska-Vassev, Katarzyna

المصدر

Evidence-Based Complementary and Alternative Medicine

العدد

المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2013-03-07

دولة النشر

مصر

عدد الصفحات

8

التخصصات الرئيسية

الطب البشري

الملخص EN

Changes in extracellular matrix glycosaminoglycans during the wound repair allowed us to apply the burn model in which therapeutic efficacy of propolis and silver sulfadiazine was compared.

Burns were inflicted on four pigs.

Glycosaminoglycans isolated from healthy and burned skin were quantified using a hexuronic acid assay, electrophoretic fractionation, and densitometric analyses.

Using the reverse-phase HPLC the profile of sulfated disaccharides released by chondroitinase ABC from chondroitin/dermatan sulfates was estimated.

Chondroitin/dermatan sulfates and hyaluronic acid were found in all samples.

Propolis stimulated significant changes in the content of particular glycosaminoglycan types during burn healing.

Glycosaminoglycans alterations after silver sulfadiazine application were less expressed.

Propolis maintained high contribution of 4-O-sulfated disaccharides to chondroitin/dermatan sulfates structure and low level of 6-O-sulfated ones throughout the observed period of healing.

Propolis led to preservation of significant contribution of disulfated disaccharides especially 2,4-O-disulfated ones to chondroitin sulfates/dermatan sulfates structure throughout the observed period of healing.

Our findings demonstrate that propolis accelerates the burned tissue repair by stimulation of the wound bed glycosaminoglycan accumulation needed for granulation, tissue growth, and wound closure.

Moreover, propolis accelerates chondroitin/dermatan sulfates structure modification responsible for binding growth factors playing the crucial role in the tissue repair.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Olczyk, Pawel& Komosinska-Vassev, Katarzyna& Winsz-Szczotka, Katarzyna& Stojko, Jerzy& Klimek, Katarzyna& Kozma, Ewa M.. 2013. Propolis Induces ChondroitinDermatan Sulphate and Hyaluronic Acid Accumulation in the Skin of Burned Wound. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-460780

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Olczyk, Pawel…[et al.]. Propolis Induces ChondroitinDermatan Sulphate and Hyaluronic Acid Accumulation in the Skin of Burned Wound. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-460780

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Olczyk, Pawel& Komosinska-Vassev, Katarzyna& Winsz-Szczotka, Katarzyna& Stojko, Jerzy& Klimek, Katarzyna& Kozma, Ewa M.. Propolis Induces ChondroitinDermatan Sulphate and Hyaluronic Acid Accumulation in the Skin of Burned Wound. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-460780

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-460780