CI431, an Aqueous Compound from Ciona intestinalis L., Induces Apoptosis through a Mitochondria-Mediated Pathway in Human Hepatocellular Carcinoma Cells
المؤلفون المشاركون
Zhang, Yuyan
Cheng, Linyou
Liu, Ming
Wang, Cuicui
Liu, Haizhou
Lin, Xiukun
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-07-21
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
In the present studies, a novel compound with potent anti-tumor activity from Ciona intestinalis L.
was purified by acetone fractionation, ultrafiltration, gel chromatography and High Performance Liquid Chromatography.
The molecular weight of the highly purified compound, designated CI431, was 431Da as determined by HPLC-MS analysis.
CI431 exhibited significant cytotoxicity to several cancer cell types.
However, only a slight inhibitory effect was found when treating the benign human liver cell line BEL-7702 with the compound.
To explore its mechanism against hepatocellular carcinoma, BEL-7402 cells were treated with CI431 in vitro.
We found that CI431 induced apoptotic death in BEL-7402 cells in a dose- and time-dependent manner.
Cell cycle analysis demonstrated that CI431 caused cell cycle arrest at the G2/M phase, and a sub-G1 peak appeared after 24 h.
The mitochondrial-mediated pathway was implicated in this CI431-induced apoptosis as evidenced by the disruption of mitochondrial membrane potential.
The results suggest that the CI431 induces apoptosis in BEL-7402 human hepatoma cells by intrinsic mitochondrial pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cheng, Linyou& Liu, Ming& Wang, Cuicui& Liu, Haizhou& Zhang, Yuyan& Lin, Xiukun. 2011. CI431, an Aqueous Compound from Ciona intestinalis L., Induces Apoptosis through a Mitochondria-Mediated Pathway in Human Hepatocellular Carcinoma Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-460996
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cheng, Linyou…[et al.]. CI431, an Aqueous Compound from Ciona intestinalis L., Induces Apoptosis through a Mitochondria-Mediated Pathway in Human Hepatocellular Carcinoma Cells. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-460996
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cheng, Linyou& Liu, Ming& Wang, Cuicui& Liu, Haizhou& Zhang, Yuyan& Lin, Xiukun. CI431, an Aqueous Compound from Ciona intestinalis L., Induces Apoptosis through a Mitochondria-Mediated Pathway in Human Hepatocellular Carcinoma Cells. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-460996
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-460996
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر