Nicotinamide, NAD(P)(H), and Methyl-Group Homeostasis Evolved and Became a Determinant of Ageing Diseases : Hypotheses and Lessons from Pellagra
المؤلفون المشاركون
Hill, Lisa J.
Ramsden, David B.
Williams, Adrian C.
المصدر
Current Gerontology and Geriatrics Research
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-24، 24ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-03-21
دولة النشر
مصر
عدد الصفحات
24
التخصصات الرئيسية
الملخص EN
Compartmentalized redox faults are common to ageing diseases.
Dietary constituents are catabolized to NAD(H) donating electrons producing proton-based bioenergy in coevolved, cross-species and cross-organ networks.
Nicotinamide and NAD deficiency from poor diet or high expenditure causes pellagra, an ageing and dementing disorder with lost robustness to infection and stress.
Nicotinamide and stress induce Nicotinamide-N-methyltransferase (NNMT) improving choline retention but consume methyl groups.
High NNMT activity is linked to Parkinson’s, cancers, and diseases of affluence.
Optimising nicotinamide and choline/methyl group availability is important for brain development and increased during our evolution raising metabolic and methylome ceilings through dietary/metabolic symbiotic means but strict energy constraints remain and life-history tradeoffs are the rule.
An optimal energy, NAD and methyl group supply, avoiding hypo and hyper-vitaminoses nicotinamide and choline, is important to healthy ageing and avoids utilising double-edged symbionts or uncontrolled autophagy or reversions to fermentation reactions in inflammatory and cancerous tissue that all redistribute NAD(P)(H), but incur high allostatic costs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Williams, Adrian C.& Hill, Lisa J.& Ramsden, David B.. 2012. Nicotinamide, NAD(P)(H), and Methyl-Group Homeostasis Evolved and Became a Determinant of Ageing Diseases : Hypotheses and Lessons from Pellagra. Current Gerontology and Geriatrics Research،Vol. 2012, no. 2012, pp.1-24.
https://search.emarefa.net/detail/BIM-461736
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Williams, Adrian C.…[et al.]. Nicotinamide, NAD(P)(H), and Methyl-Group Homeostasis Evolved and Became a Determinant of Ageing Diseases : Hypotheses and Lessons from Pellagra. Current Gerontology and Geriatrics Research No. 2012 (2012), pp.1-24.
https://search.emarefa.net/detail/BIM-461736
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Williams, Adrian C.& Hill, Lisa J.& Ramsden, David B.. Nicotinamide, NAD(P)(H), and Methyl-Group Homeostasis Evolved and Became a Determinant of Ageing Diseases : Hypotheses and Lessons from Pellagra. Current Gerontology and Geriatrics Research. 2012. Vol. 2012, no. 2012, pp.1-24.
https://search.emarefa.net/detail/BIM-461736
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-461736
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر