A Possible Novel Anti-Inflammatory Mechanism for the Pharmacological Prolyl Hydroxylase Inhibitor 3,4-Dihydroxybenzoate : Implications for Use as a Therapeutic for Parkinson’s Disease
المؤلفون المشاركون
Andersen, Julie K.
Rajagopalan, Subramanian
Ganesan, Abirami
Chinta, Shankar J.
المصدر
Mathematical Problems in Engineering
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-05-14
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Parkinson’s disease (PD) is an age-related neurodegenerative disorder characterized in part by the preferential loss of nigrostriatal dopaminergic neurons.
Although the precise etiology of PD is unknown, accumulating evidence suggests that PD involves microglial activation that exerts neurotoxic effects through production of proinflammatory cytokines and increased oxidative and nitrosative stress.
Thus, controlling microglial activation has been suggested as a therapeutic target for combating PD.
Previously we demonstrated that pharmacological inhibition of a class of enzymes known as prolyl hydroxylases via 3,4-dihydroxybenzoate administration protected against MPTP-induced neurotoxicity, however the exact mechanisms involved were not elucidated.
Here we show that this may be due to DHB’s ability to inhibit microglial activation.
DHB significantly attenuated LPS-mediated induction of nitric oxide synthase and pro-inflammatory cytokines in murine BV2 microglial cells in vitro in conjunction with reduced ROS production and activation of NFκB and MAPK pathways possibly due to up-regulation of HO-1 levels.
HO-1 inhibition partially abrogates LPS-mediated NFκB activity and subsequent NO induction.
In vivo, DHB pre-treatment suppresses microglial activation elicited by MPTP treatment.
Our results suggest that DHB’s neuroprotective properties could be due to its ability to dampen induction of microglial activation via induction of HO-1.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chinta, Shankar J.& Rajagopalan, Subramanian& Ganesan, Abirami& Andersen, Julie K.. 2012. A Possible Novel Anti-Inflammatory Mechanism for the Pharmacological Prolyl Hydroxylase Inhibitor 3,4-Dihydroxybenzoate : Implications for Use as a Therapeutic for Parkinson’s Disease. Mathematical Problems in Engineering،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-466170
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chinta, Shankar J.…[et al.]. A Possible Novel Anti-Inflammatory Mechanism for the Pharmacological Prolyl Hydroxylase Inhibitor 3,4-Dihydroxybenzoate : Implications for Use as a Therapeutic for Parkinson’s Disease. Mathematical Problems in Engineering No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-466170
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chinta, Shankar J.& Rajagopalan, Subramanian& Ganesan, Abirami& Andersen, Julie K.. A Possible Novel Anti-Inflammatory Mechanism for the Pharmacological Prolyl Hydroxylase Inhibitor 3,4-Dihydroxybenzoate : Implications for Use as a Therapeutic for Parkinson’s Disease. Mathematical Problems in Engineering. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-466170
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-466170
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر