Elevated Serum Levels of Homocysteine as an Early Prognostic Factor of Psychiatric Disorders in Children and Adolescents
المؤلفون المشاركون
Bauze, Daiga
Kevere, Laura
Piekuse, Linda
Purvina, Santa
Jelisejevs, Sergejs
Purvins, Indulis
Andrezina, Raisa
Kreile, Madara
Zeibarts, Marcis
Rizevs, Arnis
المصدر
Schizophrenia Research and Treatment
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-10-02
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background and Goal.
The aim was to examine the serum levels of homocysteine (Hcy) and their associations with the methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism in patients with schizophrenia and mood disorders as well as controls.
Materials and Methods.
There were 198 patients: 82 with schizophrenia spectrum disorders, 22 with mood disorders, and 94 controls.
The level of Hcy was determined by an isocratic high-performance liquid chromatography system.
MTHFR C677T polymorphism was analysed using the restriction fragment length polymorphism-polymerase chain reaction method.
Results.
The average level of Hcy was 11.94±5.6 μmol/L for patients with schizophrenia, 11.65±3.3 μmol/L for patients with affective disorders, versus 6.80±2.93 μmol/L in a control.
The highest level of Hcy has been observed in patients with episodic-recurrent course of schizophrenia (11.30±7.74 μmol/L), paranoid schizophrenia continuous (12.76±5.25 μmol/L), and in patients with affective disorders (11.65±3.26 μmol/L).
An association between the MTHFR gene C677T polymorphism and Hcy level was found by linear regression analysis (r=1.41, P=0.029).
Conclusions.
The data indicate a link between Hcy levels and schizophrenia and mood disorders.
No associations between the level of Hcy in patients with schizophrenia and mood disorders and the MTHFR C677T polymorphism were found.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kevere, Laura& Purvina, Santa& Bauze, Daiga& Zeibarts, Marcis& Andrezina, Raisa& Rizevs, Arnis…[et al.]. 2012. Elevated Serum Levels of Homocysteine as an Early Prognostic Factor of Psychiatric Disorders in Children and Adolescents. Schizophrenia Research and Treatment،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-466916
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kevere, Laura…[et al.]. Elevated Serum Levels of Homocysteine as an Early Prognostic Factor of Psychiatric Disorders in Children and Adolescents. Schizophrenia Research and Treatment No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-466916
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kevere, Laura& Purvina, Santa& Bauze, Daiga& Zeibarts, Marcis& Andrezina, Raisa& Rizevs, Arnis…[et al.]. Elevated Serum Levels of Homocysteine as an Early Prognostic Factor of Psychiatric Disorders in Children and Adolescents. Schizophrenia Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-466916
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-466916
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر