Repeated Intraperitoneal α-Radioimmunotherapy of Ovarian Cancer in Mice
المؤلفون المشاركون
Lindegren, Sture
Jensen, Holger
Warnhammar, Elisabet
Kahu, Helena
Hultborn, Ragnar
Elgqvist, Jörgen
Andersson, Håkan
المصدر
العدد
المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2009-10-25
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
The aim of this study was to investigate the therapeutic efficacy of α-radioimmunotherapy of ovarian cancer in mice using different fractionated treatment regimens.
The study was performed using the monoclonal antibody MX35 F(ab′)2 labeled with the α-particle emitter A211t.
Methods.
Nude mice were intraperitoneally inoculated with ~1×107 cells of the cell line NIH:OVCAR-3.
Four weeks later 6 groups of animals were given 400 kBq 211At-MX35 F(ab′)2 as a single or as a repeated treatment of up to 6 times (n=18 in each group).
The fractionated treatments were given every seventh day.
Control animals were treated with unlabeled MX35 F(ab′)2 (n=12).
Eight weeks posttreatment the animals were sacrificed and the presence of macro- and microscopic tumors and ascites was determined.
Results.
The tumor-free fractions (TFFs) of the animals, defined as the fraction of animals with no macro- and microtumors and no ascites, were 0.17, 0.11, 0.39, 0.44, 0.44, and 0.67 when treated with 400 kBq 211At-MX35 F(ab′)2 once or 2, 3, 4, 5, or 6 times, respectively.
Repeated treatment 3 times or more resulted in a significantly higher (P<.05) TFF than compared to treatment once or twice.
The presence of ascites decreased from 15 out of 18 animals in the group given only one treatment to zero for the 2 groups given 5 or 6 fractions.
Treatment with unlabeled MX35 F(ab′)2 resulted in a TFF of zero.
Conclusion.
Weekly repeated intraperitoneal injections of tolerable amounts of activity of A211t-MX35 F(ab′)2 of up to 6 times produced increased therapeutic efficacy without observed toxicity, indicating a potential increase of the therapeutic index.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Elgqvist, Jörgen& Andersson, Håkan& Jensen, Holger& Kahu, Helena& Lindegren, Sture& Warnhammar, Elisabet…[et al.]. 2009. Repeated Intraperitoneal α-Radioimmunotherapy of Ovarian Cancer in Mice. Journal of Oncology،Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-468724
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Elgqvist, Jörgen…[et al.]. Repeated Intraperitoneal α-Radioimmunotherapy of Ovarian Cancer in Mice. Journal of Oncology No. 2010 (2010), pp.1-5.
https://search.emarefa.net/detail/BIM-468724
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Elgqvist, Jörgen& Andersson, Håkan& Jensen, Holger& Kahu, Helena& Lindegren, Sture& Warnhammar, Elisabet…[et al.]. Repeated Intraperitoneal α-Radioimmunotherapy of Ovarian Cancer in Mice. Journal of Oncology. 2009. Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-468724
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-468724
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر