Bioinformatic Prediction of WSSV-Host Protein-Protein Interaction
المؤلفون المشاركون
Sun, Zheng
Li, Fuhua
Xiang, Jianhai
Li, Shihao
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-19
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
WSSV is one of the most dangerous pathogens in shrimp aquaculture.
However, the molecular mechanism of how WSSV interacts with shrimp is still not very clear.
In the present study, bioinformatic approaches were used to predict interactions between proteins from WSSV and shrimp.
The genome data of WSSV (NC_003225.1) and the constructed transcriptome data of F.
chinensis were used to screen potentially interacting proteins by searching in protein interaction databases, including STRING, Reactome, and DIP.
Forty-four pairs of proteins were suggested to have interactions between WSSV and the shrimp.
Gene ontology analysis revealed that 6 pairs of these interacting proteins were classified into “extracellular region” or “receptor complex” GO-terms.
KEGG pathway analysis showed that they were involved in the “ECM-receptor interaction pathway.” In the 6 pairs of interacting proteins, an envelope protein called “collagen-like protein” (WSSV-CLP) encoded by an early virus gene “wsv001” in WSSV interacted with 6 deduced proteins from the shrimp, including three integrin alpha (ITGA), two integrin beta (ITGB), and one syndecan (SDC).
Sequence analysis on WSSV-CLP, ITGA, ITGB, and SDC revealed that they possessed the sequence features for protein-protein interactions.
This study might provide new insights into the interaction mechanisms between WSSV and shrimp.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sun, Zheng& Li, Shihao& Li, Fuhua& Xiang, Jianhai. 2014. Bioinformatic Prediction of WSSV-Host Protein-Protein Interaction. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-470464
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sun, Zheng…[et al.]. Bioinformatic Prediction of WSSV-Host Protein-Protein Interaction. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-470464
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sun, Zheng& Li, Shihao& Li, Fuhua& Xiang, Jianhai. Bioinformatic Prediction of WSSV-Host Protein-Protein Interaction. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-470464
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-470464
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر