![](/images/graphics-bg.png)
Statin Modulation of Human T-Cell Proliferation, IL-1β and IL-17 Production, and IFN-γ T Cell Expression : Synergy with Conventional Immunosuppressive Agents
المؤلفون المشاركون
Ooi, Kenneth G.-J.
Calder, Virginia L.
Jameel, Ashmal
Lightman, Susan L.
Jeffs, Natasha R.
Galatowicz, Grazyna
المصدر
International Journal of Inflammation
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-09-18
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
HMG-CoA reductase inhibitors (statins) have been demonstrated to be immunomodulatory for human immune-mediated disease and in experimental models.
The aim of this study was to compare statin-mediated immunosuppressive effects on human T-cell responses in vitro with those of conventional immunosuppressives (dexamethasone, cyclosporin A (CsA), mycophenolate, and rapamycin).
Statins (atorvastatin, lovastatin, and simvastatin) were investigated for their modulatory effects on human PBMC viability, cytokine profiles, and T-cell proliferation.
At concentrations that inhibited anti-CD3/28-stimulated T-cell proliferation (P<0.01), simvastatin significantly decreased intracellular CD4+ T-cell expression of IFN-γ (P<0.01) to levels similar to those induced by conventional immunosuppressives.
Atorvastatin and lovastatin also decreased IFN-γ expression, although to a lesser degree (P<0.05).
All three statins reduced levels of IL-17 production (P<0.01).
However, in response to anti-CD3/28 stimulation, simvastatin significantly upregulated IL-1β production (P<0.05).
The profile of cytokines produced in response to anti-CD3/28 stimulation was similar when both atorvastatin and dexamethasone were added as compared with dexamethasone alone, suggesting that atorvastatin can synergise with dexamethasone with respect to immunomodulation of cytokines.
This data supports the hypothesis of selective statin-mediated immunomodulatory effects on human immune cells.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jameel, Ashmal& Ooi, Kenneth G.-J.& Jeffs, Natasha R.& Galatowicz, Grazyna& Lightman, Susan L.& Calder, Virginia L.. 2013. Statin Modulation of Human T-Cell Proliferation, IL-1β and IL-17 Production, and IFN-γ T Cell Expression : Synergy with Conventional Immunosuppressive Agents. International Journal of Inflammation،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-471949
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jameel, Ashmal…[et al.]. Statin Modulation of Human T-Cell Proliferation, IL-1β and IL-17 Production, and IFN-γ T Cell Expression : Synergy with Conventional Immunosuppressive Agents. International Journal of Inflammation No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-471949
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jameel, Ashmal& Ooi, Kenneth G.-J.& Jeffs, Natasha R.& Galatowicz, Grazyna& Lightman, Susan L.& Calder, Virginia L.. Statin Modulation of Human T-Cell Proliferation, IL-1β and IL-17 Production, and IFN-γ T Cell Expression : Synergy with Conventional Immunosuppressive Agents. International Journal of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-471949
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-471949
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)