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α-Mangostin from Cratoxylum arborescens (Vahl) Blume Demonstrates Anti-Ulcerogenic Property : A Mechanistic Study
المؤلفون المشاركون
Mohamed Elhassan Taha, Manal
Abdel Wahab, Siddig Ibrahim
Loke Fai, Mun
Mohan, Syam
Hashim, Najihah Mohd
Vadivelu, Jamunarani
Abdulla, Mahmood Ameen
Hadi, A. Hamid A.
Sidahmed, Heyam M. A.
Yahayu, Maizatulakmal
Rahmani, Mawardi
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-03-24
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Cratoxylum arborescens (Vahl) Blume is an Asian herbal medicine with versatile ethnobiological properties including treatment of gastric ulcer.
This study evaluated the antiulcerogenic mechanism(s) of α-mangostin (AM) in a rat model of ulcer.
AM is a prenylated xanthone derived through biologically guided fractionation of C.
arborescens.
Rats were orally pretreated with AM and subsequently exposed to acute gastric lesions induced by ethanol.
Following treatment, ulcer index, gastric juice acidity, mucus content, histological and immunohistochemical analyses, glutathione (GSH), malondialdehyde (MDA), nitric oxide (NO), and nonprotein sulfhydryl groups (NP-SH) were evaluated.
The anti-Helicobacter pylori, cyclooxygenase-2 (COX-2) inhibitory effect, and antioxidant activity of AM were also investigated in vitro.
AM (10 and 30 mg/kg) inhibited significantly (P<0.05) ethanol-induced gastric lesions by 66.04% and 74.39 %, respectively.
The compound induces the expression of Hsp70, restores GSH levels, decreases lipid peroxidation, and inhibits COX-2 activity.
The minimum inhibitory concentration (MIC) of AM showed an effective in vitro anti-H.
pylori activity.
The efficacy of the AM was accomplished safely without presenting any toxicological parameters.
The results of the present study indicate that the antioxidant properties and the potent anti-H.
pylori, in addition to activation of Hsp70 protein, may contribute to the gastroprotective activity of α-mangostin.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sidahmed, Heyam M. A.& Abdel Wahab, Siddig Ibrahim& Mohan, Syam& Abdulla, Mahmood Ameen& Mohamed Elhassan Taha, Manal& Hashim, Najihah Mohd…[et al.]. 2013. α-Mangostin from Cratoxylum arborescens (Vahl) Blume Demonstrates Anti-Ulcerogenic Property : A Mechanistic Study. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-472577
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sidahmed, Heyam M. A.…[et al.]. α-Mangostin from Cratoxylum arborescens (Vahl) Blume Demonstrates Anti-Ulcerogenic Property : A Mechanistic Study. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-472577
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sidahmed, Heyam M. A.& Abdel Wahab, Siddig Ibrahim& Mohan, Syam& Abdulla, Mahmood Ameen& Mohamed Elhassan Taha, Manal& Hashim, Najihah Mohd…[et al.]. α-Mangostin from Cratoxylum arborescens (Vahl) Blume Demonstrates Anti-Ulcerogenic Property : A Mechanistic Study. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-472577
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-472577
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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