Bone Mineral Density in Cystic Fibrosis Patients with the CFTR I1234V Mutation in a Large Kindred Family Is Associated with Pancreatic Sufficiency
المؤلفون المشاركون
Chandra, Prem
Hammoudeh, Mohammed
Abdul Wahab, Atqah
al-Khalaf, Fawziya
Allangawi, Mona
المصدر
International Journal of Rheumatology
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-30
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Objectives.
To study bone mineral density (BMD) in cystic fibrosis (CF) children and adults with the CFTR I1234V mutation associated with pancreatic sufficiency.
Methods.
Lumbar spine, total hip, and whole-body mineral density were measured by dual-energy radiographic absorptiometry (DEXA) scan.
Z score was used for those less than 21 years and T score was used for those 21 years or older.
Results.
Twenty-one CF patients were younger than 21 years and 5 CF patients were 21 years or older.
Mean age was 17.29 ± 4.95 years, ranging from 10 to 33 years.
The mean BMD Z scores for patients younger than 21 years were −0.69 ± 0.96 (lumbar spine = L1–L4), −0.48 ± 0.92 (total hip), and −0.38 ± 0.86 (total body).
The mean T scores for patients 21 years or older were 0.14 ± 0.7 (L1–L4), 0.38 ± 1 (total hip), and 0.52 ± 1.03 (total body).
BMD reduction less than −1 was found in 7 (26.9%) CF patients.
Vitamin D deficiency in 20 CF patients (76.9%) tended to be lower in CF patients with low BMD.
BMD was significantly correlated with FEV1; however, no significant association was observed with P.
aeruginosa colonization.
Conclusion.
BMD reduction does occur in patients with mild CFTR mutation associated with pancreatic sufficiency.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abdul Wahab, Atqah& Hammoudeh, Mohammed& Allangawi, Mona& al-Khalaf, Fawziya& Chandra, Prem. 2014. Bone Mineral Density in Cystic Fibrosis Patients with the CFTR I1234V Mutation in a Large Kindred Family Is Associated with Pancreatic Sufficiency. International Journal of Rheumatology،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-473733
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abdul Wahab, Atqah…[et al.]. Bone Mineral Density in Cystic Fibrosis Patients with the CFTR I1234V Mutation in a Large Kindred Family Is Associated with Pancreatic Sufficiency. International Journal of Rheumatology No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-473733
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abdul Wahab, Atqah& Hammoudeh, Mohammed& Allangawi, Mona& al-Khalaf, Fawziya& Chandra, Prem. Bone Mineral Density in Cystic Fibrosis Patients with the CFTR I1234V Mutation in a Large Kindred Family Is Associated with Pancreatic Sufficiency. International Journal of Rheumatology. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-473733
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-473733
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر