Influence of Secondary Hyperparathyroidism Induced by Low Dietary Calcium, Vitamin D Deficiency, and Renal Failure on Circulating Rat PTH Molecular Forms

المؤلفون المشاركون

D'Amour, Pierre
Rousseau, Louise
Yang, Zan
Hornyak, Stephen
Cantor, Tom

المصدر

International Journal of Endocrinology

العدد

المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-10، 10ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2011-06-22

دولة النشر

مصر

عدد الصفحات

10

التخصصات الرئيسية

الأحياء

الملخص EN

Rats(r) with secondary hyperparathyroidism were studied to define the relationship between vitamin D metabolites and rPTH levels measured by 3 different rat ELISAs.

Controls and renal failure (RF) rats were on a normal diet, while 2 groups on a low-calcium (-Ca) or a vitamin D-deficient (-D) diet.

RF was induced surgically.

Mild RF rats had normal calcium and 25(OH)D but reduced 1,25(OH)2D levels (P<.001) with a 2.5-fold increased in rPTH (P<.001).

Severe RF rats and those on a -Ca or -D diet had reduced calcium (P<.01) and 25(OH)D levels (P<.05), with rPTH increased by 2 (-Ca diet; P<.05), 4 (-D diet; P<.001), and 20-folds (RF; P<.001) while 1,25(OH)2D was high (-Ca diet: P<.001) or low (-D diet, RF: P<.001).

25(OH)D and 1,25(OH)2D were positively and negatively related on the -Ca and -D diets, respectively.

rPTH molecular forms behaved as expected in RF and on -Ca diet, but not on -D diet with more C-rPTH fragments when less were expected.

This may be related to the short-time course of this study compared to prior studies.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

D'Amour, Pierre& Rousseau, Louise& Hornyak, Stephen& Yang, Zan& Cantor, Tom. 2011. Influence of Secondary Hyperparathyroidism Induced by Low Dietary Calcium, Vitamin D Deficiency, and Renal Failure on Circulating Rat PTH Molecular Forms. International Journal of Endocrinology،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-474020

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

D'Amour, Pierre…[et al.]. Influence of Secondary Hyperparathyroidism Induced by Low Dietary Calcium, Vitamin D Deficiency, and Renal Failure on Circulating Rat PTH Molecular Forms. International Journal of Endocrinology No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-474020

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

D'Amour, Pierre& Rousseau, Louise& Hornyak, Stephen& Yang, Zan& Cantor, Tom. Influence of Secondary Hyperparathyroidism Induced by Low Dietary Calcium, Vitamin D Deficiency, and Renal Failure on Circulating Rat PTH Molecular Forms. International Journal of Endocrinology. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-474020

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-474020