Human Paraoxonase-1 Activity Is Related to the Number of CD4+ T-Cells and Is Restored by Antiretroviral Therapy in HIV-1-Infected Individuals
المؤلفون المشاركون
Gutierrez, Eliana Battaggia
Maselli, Luciana Morganti Ferreira
Spada, Celso
Maranhão, Raul Cavalcante
Bydlowski, Sérgio Paulo
Cunha, Joel da
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-02-26
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Paraoxonase-1 (PON1) activity is suggested to be altered in individuals infected with human immunodeficiency virus type-1 (HIV-1).
We investigated PON1 activity in individuals receiving different regimens of highly active antiretroviral therapy (HAART).
Methods.
PON1 activity was evaluated in 91 HIV-1 seronegative and 624 HIV-1 infected individuals (115 were not undergoing therapy (ART-naïve), and 509 were receiving HAART).
HIV-1 infected individuals were treated with the following: efavirenz (EFV; n=195) or nevirapine (NVP; n=95) or lopinavir/ritonavir (LOP/r; n=219).
Serum levels of total cholesterol (TC), HDL, and low-density lipoprotein (LDL) fractions and the atherogenic indices (AI, TC : HDL, and LDL : HDL ratios) were determined.
Results.
PON1 activity (U/L) was lower in the ART-naïve group compared with the other groups.
PON1 activity correlated with CD4+ T-cell number of ART-naïve group (r=0,121; P=0,014).
The LOP/r group showed a reduction in HDL and an increase in AI (TC : HDL ratio) in comparison with other groups.
Conclusion.
PON1 activity was reduced in untreated individuals, but not in individuals receiving HAART.
PON1 activity correlated with the number of CD4+ T-cells.
The findings suggest that the activity of PON1 is associated with the immune status of HIV-1 infected individuals.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Maselli, Luciana Morganti Ferreira& Cunha, Joel da& Gutierrez, Eliana Battaggia& Maranhão, Raul Cavalcante& Spada, Celso& Bydlowski, Sérgio Paulo. 2014. Human Paraoxonase-1 Activity Is Related to the Number of CD4+ T-Cells and Is Restored by Antiretroviral Therapy in HIV-1-Infected Individuals. Disease Markers،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-474863
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Maselli, Luciana Morganti Ferreira…[et al.]. Human Paraoxonase-1 Activity Is Related to the Number of CD4+ T-Cells and Is Restored by Antiretroviral Therapy in HIV-1-Infected Individuals. Disease Markers No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-474863
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Maselli, Luciana Morganti Ferreira& Cunha, Joel da& Gutierrez, Eliana Battaggia& Maranhão, Raul Cavalcante& Spada, Celso& Bydlowski, Sérgio Paulo. Human Paraoxonase-1 Activity Is Related to the Number of CD4+ T-Cells and Is Restored by Antiretroviral Therapy in HIV-1-Infected Individuals. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-474863
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-474863
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر