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A 3’UTR Polymorphism of IL-6R Is Associated with Chinese Pediatric Tuberculosis
المؤلفون المشاركون
Wu, Xi-rong
Tian, Jian-ling
Qi, Hui
Sun, Lin
Yin, Qing-qin
Xiao, Jing
Shen, Chen
Shen, A-dong
Han, Rui
Jiao, Wei-wei
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-19
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
IL-6 is a proinflammatory cytokine that plays a critical role in host defense against tuberculosis (TB).
Genetic polymorphisms of IL-6 and its receptor IL-6R had been discussed in adult TB recently.
However, their role in pediatric TB is still unclear.
Due to the obvious differences in TB pathophysiology in children, which may also reflect differences in genetic background, further association studies in pediatric populations are needed.
Methods.
A case-control study was carried out in a Chinese pediatric population including 353 TB patients and 400 healthy controls.
Tag-SNPs of IL-6 and IL-6R genes were selected by Haploview software, genotyped using MassArray, and analyzed statistically.
Results.
One polymorphism, rs2229238, in the 3’UTR region of IL-6R was observed to be associated with increased resistance to TB (adjusted P = 0.03).
The rs2229238 T allele contributed to a reduced risk to TB in recessive heritable model (OR, 0.53; 95% CI, 0.35–0.78).
Conclusions.
By tag-SNP genotyping based case-control study, we identified a genetic polymorphism in the IL-6R 3’UTR that regulates host resistance to pediatric TB in a Chinese population.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shen, Chen& Qi, Hui& Sun, Lin& Xiao, Jing& Yin, Qing-qin& Jiao, Wei-wei…[et al.]. 2014. A 3’UTR Polymorphism of IL-6R Is Associated with Chinese Pediatric Tuberculosis. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-475235
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shen, Chen…[et al.]. A 3’UTR Polymorphism of IL-6R Is Associated with Chinese Pediatric Tuberculosis. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-475235
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shen, Chen& Qi, Hui& Sun, Lin& Xiao, Jing& Yin, Qing-qin& Jiao, Wei-wei…[et al.]. A 3’UTR Polymorphism of IL-6R Is Associated with Chinese Pediatric Tuberculosis. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-475235
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-475235
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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