Highly Elevated Serum Hepcidin in Patients with Acute Myeloid Leukemia prior to and after Allogeneic Hematopoietic Cell Transplantation : Does This Protect from Excessive Parenchymal Iron Loading?
المؤلفون المشاركون
Teupser, Daniel
Krahl, Rainer
Westerman, Mark
Liebert, Uwe Gerd
al-Ali, Haifa Kathrin
Niederwieser, Dietger
Hehme, Marianne
Eisfeld, Ann-Kathrin
Leiblein, Sabine
المصدر
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-05-05
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Hepcidin is upregulated by inflammation and iron.
Inherited (HFE genotype) and treatment-related factors (blood units (BU), Iron overload) affecting hepcidin (measured by C-ELISA) were studied in 42 consecutive patients with AML prior to and after allogeneic hematopoietic cell transplantation (HCT).
Results.
Elevated serum ferritin pre- and post-HCT was present in all patients.
Median hepcidin pre- and post-HCT of 358 and 398 ng/mL, respectively, were elevated compared to controls (median 52 ng/mL) (P<.0001).
Liver and renal function, prior chemotherapies, and conditioning had no impact on hepcidin.
Despite higher total BU after HCT compared to pretransplantation (P<.0005), pre- and posttransplant ferritin and hepcidin were similar.
BU influenced ferritin (P=.001) and hepcidin (P=.001).
No correlation of pre- or posttransplant hepcidin with pretransplant ferritin was found.
HFE genotype did not influence hepcidin.
Conclusions.
Hepcidin is elevated in AML patients pre- and post-HCT due to transfusional iron-loading suggesting that hepcidin synthesis remains intact despite chemotherapy and HCT.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Eisfeld, Ann-Kathrin& Westerman, Mark& Krahl, Rainer& Leiblein, Sabine& Liebert, Uwe Gerd& Hehme, Marianne…[et al.]. 2011. Highly Elevated Serum Hepcidin in Patients with Acute Myeloid Leukemia prior to and after Allogeneic Hematopoietic Cell Transplantation : Does This Protect from Excessive Parenchymal Iron Loading?. Advances in Hematology،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-475830
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Eisfeld, Ann-Kathrin…[et al.]. Highly Elevated Serum Hepcidin in Patients with Acute Myeloid Leukemia prior to and after Allogeneic Hematopoietic Cell Transplantation : Does This Protect from Excessive Parenchymal Iron Loading?. Advances in Hematology No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-475830
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Eisfeld, Ann-Kathrin& Westerman, Mark& Krahl, Rainer& Leiblein, Sabine& Liebert, Uwe Gerd& Hehme, Marianne…[et al.]. Highly Elevated Serum Hepcidin in Patients with Acute Myeloid Leukemia prior to and after Allogeneic Hematopoietic Cell Transplantation : Does This Protect from Excessive Parenchymal Iron Loading?. Advances in Hematology. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-475830
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-475830
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر