Intraindividual Variability in Domain-Specific Cognition and Risk of Mild Cognitive Impairment and Dementia

المؤلفون المشاركون

Gaussoin, Sarah A.
Leng, Iris
Coker, Laura H.
Dagenbach, Dale
Espeland, Mark A.
Simpson, Sean L.
Vaughan, Leslie
Brunner, Robert L.
Rapp, Stephen R.
Jennings, Janine M.
Resnick, Susan M.
Sink, Kaycee M.
Beavers, Daniel P.

المصدر

Current Gerontology and Geriatrics Research

العدد

المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2013-12-22

دولة النشر

مصر

عدد الصفحات

10

التخصصات الرئيسية

الأمراض

الملخص EN

Intraindividual variability among cognitive domains may predict dementia independently of interindividual differences in cognition.

A multidomain cognitive battery was administered to 2305 older adult women (mean age 74 years) enrolled in an ancillary study of the Women’s Health Initiative.

Women were evaluated annually for probable dementia and mild cognitive impairment (MCI) for an average of 5.3 years using a standardized protocol.

Proportional hazards regression showed that lower baseline domain-specific cognitive scores significantly predicted MCI (N=74), probable dementia (N=45), and MCI or probable dementia combined (N=101) and that verbal and figural memory predicted each outcome independently of all other cognitive domains.

The baseline intraindividual standard deviation across test scores (IAV Cognitive Domains) significantly predicted probable dementia and this effect was attenuated by interindividual differences in verbal episodic memory.

Slope increases in IAV Cognitive Domains across measurement occasions (IAV Time) explained additional risk for MCI and MCI or probable dementia, beyond that accounted for by interindividual differences in multiple cognitive measures, but risk for probable dementia was attenuated by mean decreases in verbal episodic memory slope.

These findings demonstrate that within-person variability across cognitive domains both at baseline and longitudinally independently accounts for risk of cognitive impairment and dementia in support of the predictive utility of within-person variability.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Vaughan, Leslie& Leng, Iris& Dagenbach, Dale& Resnick, Susan M.& Rapp, Stephen R.& Jennings, Janine M.…[et al.]. 2013. Intraindividual Variability in Domain-Specific Cognition and Risk of Mild Cognitive Impairment and Dementia. Current Gerontology and Geriatrics Research،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-476247

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Vaughan, Leslie…[et al.]. Intraindividual Variability in Domain-Specific Cognition and Risk of Mild Cognitive Impairment and Dementia. Current Gerontology and Geriatrics Research No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-476247

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Vaughan, Leslie& Leng, Iris& Dagenbach, Dale& Resnick, Susan M.& Rapp, Stephen R.& Jennings, Janine M.…[et al.]. Intraindividual Variability in Domain-Specific Cognition and Risk of Mild Cognitive Impairment and Dementia. Current Gerontology and Geriatrics Research. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-476247

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-476247