Association between Preoperative Plasma sRAGE Levels and Recovery from Cardiac Surgery
المؤلفون المشاركون
Burke-Gaffney, Anne
Quinlan, Gregory J.
Evans, Timothy W.
Hector, Lauren R.
Creagh-Brown, Benedict C.
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-09-05
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
The receptor for advanced glycation end products (RAGE) is an inflammation-perpetuating receptor, and soluble RAGE (sRAGE) is a marker of cellular RAGE expression.
This study investigated whether raised plasma levels prior to surgery of sRAGE or S100A8/A9 (a RAGE ligand) were associated with longer duration of hospital care in patients undergoing cardiac surgery necessitating cardiopulmonary bypass.
Methods.
Patients (n=130) undergoing elective cardiac surgery were enrolled prospectively.
Plasma sRAGE and S100A8/A9 concentrations were measured before and 2 h after surgery.
Results.
Preoperative plasma sRAGE increased significantly (P<0.0001) from 1.06 ng/mL (IQR, 0.72–1.76) to 1.93 ng/mL (IQR, 1.14–2.63) 2 h postoperatively.
Plasma S100A8/9 was also significantly (P<0.0001) higher 2 h postoperatively (2.37 μg/mL, IQR, 1.81–3.05) compared to pre-operative levels (0.41 μg/mL, IQR, 0.2–0.65).
Preoperative sRAGE, but not S100A8/A9, was positively and significantly correlated with duration of critical illness (r=0.3, P=0.0007) and length of hospital stay (LOS; r=0.31, P<0.0005).
Multivariate binary logistic regression showed preoperative sRAGE to be, statistically, an independent predictor of greater than median duration of critical illness (odds ratio 16.6, P=0.014) and to be, statistically, the strongest independent predictor of hospital LOS.
Conclusion.
Higher preoperative plasma sRAGE levels were associated with prolonged duration of care in adults undergoing cardiac surgery requiring cardiopulmonary bypass.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Creagh-Brown, Benedict C.& Quinlan, Gregory J.& Hector, Lauren R.& Evans, Timothy W.& Burke-Gaffney, Anne. 2013. Association between Preoperative Plasma sRAGE Levels and Recovery from Cardiac Surgery. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-476276
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Creagh-Brown, Benedict C.…[et al.]. Association between Preoperative Plasma sRAGE Levels and Recovery from Cardiac Surgery. Mediators of Inflammation No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-476276
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Creagh-Brown, Benedict C.& Quinlan, Gregory J.& Hector, Lauren R.& Evans, Timothy W.& Burke-Gaffney, Anne. Association between Preoperative Plasma sRAGE Levels and Recovery from Cardiac Surgery. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-476276
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-476276
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر