Diagnostic Performance of Des-γ-carboxy Prothrombin for Hepatocellular Carcinoma : A Meta-Analysis
المؤلفون المشاركون
Lu, Jie
Li, Jingjing
Wang, Fan
Zhang, Huawei
Yang, Jing
Shen, Miao
Zheng, Yuanyuan
Cheng, Ping
Wang, Chengfen
Zhou, Ying-Qun
Chen, Kan
Zhu, Rong
Zhang, Yan
Guo, Chuan-Yong
Xu, Ling
Weiqi, Dai
Wu, Dong
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-08-06
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
There have been many reports on des-γ-carboxy prothrombin (DCP) as a promising serum marker in the diagnosis of hepatocellular carcinoma (HCC); however, the results are inconsistent and even conflicting.
Methods.
This meta-analysis was performed to investigate the performance of DCP in the diagnosis of HCC.
Following a systematic review of relevant studies, Meta-DiSc 1.4 software was used to extract data and to calculate the overall sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), and diagnostic odds ratio (DOR).
Data are presented as forest plots and summary receiver operating characteristic curve (SROC) analysis was used to summarize the overall test performance.
Results.
Twelve studies were included in our meta-analysis.
The overall sensitivity, specificity, PLR, and NLR of DCP for the detection of HCC in the studies included were 71% (95%CI: 68%–73%), 84% (95%CI: 83%–86%), 6.48 (95%CI: 4.22–9.93), and 0.33 (95%CI: 0.25–0.43), respectively.
The area under the SROC curve was 0.8930 and the Q index was 0.8238.
Significant heterogeneity was found.
Conclusion.
This meta-analysis indicated that DCP had moderate diagnostic accuracy in HCC.
Further studies with rigorous design, large sample size, and mmultiregional cooperation are needed in the future.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhu, Rong& Yang, Jing& Xu, Ling& Weiqi, Dai& Wang, Fan& Shen, Miao…[et al.]. 2014. Diagnostic Performance of Des-γ-carboxy Prothrombin for Hepatocellular Carcinoma : A Meta-Analysis. Gastroenterology Research and Practice،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-478988
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhu, Rong…[et al.]. Diagnostic Performance of Des-γ-carboxy Prothrombin for Hepatocellular Carcinoma : A Meta-Analysis. Gastroenterology Research and Practice No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-478988
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhu, Rong& Yang, Jing& Xu, Ling& Weiqi, Dai& Wang, Fan& Shen, Miao…[et al.]. Diagnostic Performance of Des-γ-carboxy Prothrombin for Hepatocellular Carcinoma : A Meta-Analysis. Gastroenterology Research and Practice. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-478988
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-478988
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر