Early Detection of Tumor Response by FLTMicroPET Imaging in a C26 Murine Colon Carcinoma Solid Tumor Animal Model
المؤلفون المشاركون
Chen, Liang-Cheng
Ho, Chung-Li
Lee, Wan-Chi
Chang, Chih-Hsien
Lee, Te-Wei
Chen, Jenn-Tzong
Wang, Ying-Ling
Wu, Yu-Hsien
المصدر
Journal of Biomedicine and Biotechnology
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-08-16
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Fluorine-18 fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) imaging demonstrated the change of glucose consumption of tumor cells, but problems with specificity and difficulties in early detection of tumor response to chemotherapy have led to the development of new PET tracers.
Fluorine-18-fluorothymidine (18F-FLT) images cellular proliferation by entering the salvage pathway of DNA synthesis.
In this study, we evaluate the early response of colon carcinoma to the chemotherapeutic drug, lipo-Dox, in C26 murine colorectal carcinoma-bearing mice by 18F-FDG and 18F-FLT.
The male BALB/c mice were bilaterally inoculated with 1×105 and 1×106 C26 tumor cells per flank.
Mice were intravenously treated with 10 mg/kg lipo-Dox at day 8 after 18F-FDG and 18F-FLT imaging.
The biodistribution of 18F-FDG and 18F-FLT were followed by the microPET imaging at day 9.
For the quantitative measurement of microPET imaging at day 9, 18F-FLT was superior to 18F-FDG for early detection of tumor response to Lipo-DOX at various tumor sizes (P<0.05).
The data of biodistribution showed similar results with those from the quantification of SUV (standard uptake value) by microPET imaging.
The study indicates that 18F-FLT/microPET is a useful imaging modality for early detection of chemotherapy in the colorectal mouse model.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lee, Wan-Chi& Chang, Chih-Hsien& Ho, Chung-Li& Chen, Liang-Cheng& Wu, Yu-Hsien& Chen, Jenn-Tzong…[et al.]. 2011. Early Detection of Tumor Response by FLTMicroPET Imaging in a C26 Murine Colon Carcinoma Solid Tumor Animal Model. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-479467
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lee, Wan-Chi…[et al.]. Early Detection of Tumor Response by FLTMicroPET Imaging in a C26 Murine Colon Carcinoma Solid Tumor Animal Model. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-479467
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lee, Wan-Chi& Chang, Chih-Hsien& Ho, Chung-Li& Chen, Liang-Cheng& Wu, Yu-Hsien& Chen, Jenn-Tzong…[et al.]. Early Detection of Tumor Response by FLTMicroPET Imaging in a C26 Murine Colon Carcinoma Solid Tumor Animal Model. Journal of Biomedicine and Biotechnology. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-479467
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-479467
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر