Abnormal Behaviors and Microstructural Changes in White Matter of Juvenile Mice Repeatedly Exposed to Amphetamine
المؤلفون المشاركون
Yang, Hong-Ju
Wang, Lijun
Cheng, Qiang
Xu, Haiyun
المصدر
Schizophrenia Research and Treatment
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-06-29
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Amphetamine (AMP) is an addictive CNS stimulant and has been commonly abused by adolescents and young adults, during which period brain white matter is still developing.
This study was to examine the effect of a nonneurotoxic AMP on the white matter of juvenile mice.
d-AMP (1.0 mg/kg) was given to young male C57BL/6 mice once a day for 21 days.
The spatial working memory and locomotion of mice were measured at the end.
Then, mice were sacrificed and their brains were processed for morphological analyses to examine the white matter structure and for Western blot analysis to measure three main proteins expressed in mature oligodendrocytes.
AMP-treated mice displayed higher locomotion and spatial working memory impairment and showed lower levels of Nogo-A and GST-pi proteins in frontal cortex and lower MBP protein in the frontal cortex and hippocampus.
They also had fewer mature oligodendrocytes and weak MBP immunofluorescent staining in the same two brain regions.
But the striatum was spared.
These results suggest that the late-developing white matter is vulnerable to AMP treatment which is able to increase striatal and cortical dopamine.
Both the compromised white matter and increased dopamine may contribute to the observed behavioral changes in AMP-treated mice.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yang, Hong-Ju& Wang, Lijun& Cheng, Qiang& Xu, Haiyun. 2011. Abnormal Behaviors and Microstructural Changes in White Matter of Juvenile Mice Repeatedly Exposed to Amphetamine. Schizophrenia Research and Treatment،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-480143
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yang, Hong-Ju…[et al.]. Abnormal Behaviors and Microstructural Changes in White Matter of Juvenile Mice Repeatedly Exposed to Amphetamine. Schizophrenia Research and Treatment No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-480143
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yang, Hong-Ju& Wang, Lijun& Cheng, Qiang& Xu, Haiyun. Abnormal Behaviors and Microstructural Changes in White Matter of Juvenile Mice Repeatedly Exposed to Amphetamine. Schizophrenia Research and Treatment. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-480143
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-480143
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر