Clinicopathological Characteristics and Her-2neu Status in Chinese Patients with Uterine Papillary Serous Carcinoma
المؤلفون المشاركون
Yang, Wentao
Huang, Xiaowei
Shi, Daren
Ren, Yulan
Lu, Yongming
Wang, Huaying
Zhou, Xiaoyan
المصدر
ISRN Obstetrics and Gynecology
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-10-20
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Objective.
To analyze clinico-pathological features of Chinese patients with UPSC, and investigate roles of Her-2/neu protein expression and gene amplification in UPSC prognosis.
Methods.
Thirty-six patients with UPSC treated in Cancer Hospital of Fudan University from 1996 to 2006 were analysed retrospectively.
Chromogenic in situ hybridization (CISH) and immunohistochemistry (IHC) were performed to evaluate Her-2/neu gene amplification and protein expression respectively.
Results.
The median age was 63 years, and 61% (22/36) were late stages (stage III/IV).
The 1-year, 3-year, and 5-year overall survival (OS) was 73.1%, 51.9% and 43.9%, respectively.
Advanced stages (P=.0006) and deep myometrial invasion (P=.0138) were significantly associtated with a shorter OS.
In 36 cases, 27.8% (10/36) showed 2+ staining and 8.3% (3/36) showed 3+ by IHC.
Amplification of the Her-2/neu gene was observed in 11.1% (4/36) cases.
The 5-year overall survival rate in Her-2/neu IHC 2+∼3+ and 0∼1+ cases was 12.9% and 68.6% respectively.
Her-2/neu protein expression 2+∼3+ was significantly associated with advanced surgical stage and worse overall survival (P=.03 and P=.0023, resp.).
Conclusion.
Chinese patients with UPSC showed characteristics of deep myometrial invasion, advanced stages and poor overall survival.
Her-2/neu protein overexpression is associated with advanced stage and poor survival outcome.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ren, Yulan& Wang, Huaying& Zhou, Xiaoyan& Yang, Wentao& Huang, Xiaowei& Lu, Yongming…[et al.]. 2010. Clinicopathological Characteristics and Her-2neu Status in Chinese Patients with Uterine Papillary Serous Carcinoma. ISRN Obstetrics and Gynecology،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-482028
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ren, Yulan…[et al.]. Clinicopathological Characteristics and Her-2neu Status in Chinese Patients with Uterine Papillary Serous Carcinoma. ISRN Obstetrics and Gynecology No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-482028
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ren, Yulan& Wang, Huaying& Zhou, Xiaoyan& Yang, Wentao& Huang, Xiaowei& Lu, Yongming…[et al.]. Clinicopathological Characteristics and Her-2neu Status in Chinese Patients with Uterine Papillary Serous Carcinoma. ISRN Obstetrics and Gynecology. 2010. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-482028
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-482028
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر