CYP2E1 Sensitizes the Liver to LPS- and TNF α-Induced Toxicity via Elevated Oxidative and Nitrosative Stress and Activation of ASK-1 and JNK Mitogen-Activated Kinases
المؤلفون المشاركون
Wu, Defeng
Wang, Xiaodong
Yang, Lili
Cederbaum, Arthur I.
المصدر
International Journal of Hepatology
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-19، 19ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-10-18
دولة النشر
مصر
عدد الصفحات
19
التخصصات الرئيسية
الملخص EN
The mechanisms by which alcohol causes cell injury are not clear.
A major mechanism is the role of lipid peroxidation and oxidative stress in alcohol toxicity.
Many pathways have been suggested to play a role in how alcohol induces oxidative stress.
Considerable attention has been given to alcohol elevated production of lipopolysaccharide (LPS) and TNFα and to alcohol induction of CYP2E1.
These two pathways are not exclusive of each other; however, interactions between them, have not been extensively evaluated.
Increased oxidative stress from induction of CYP2E1 sensitizes hepatocytes to LPS and TNFα toxicity and oxidants, activation of inducible nitric oxide synthase and p38 and JNK MAP kinases, and mitochondrial dysfunction are downstream mediators of this CYP2E1-LPS/TNFα-potentiated hepatotoxicity.
This paper will summarize studies showing potentiated interactions between these two risk factors in promoting liver injury and the mechanisms involved including activation of the mitogen-activated kinase kinase kinase ASK-1.
Decreasing either cytosolic or mitochondrial thioredoxin in HepG2 cells expressing CYP2E1 causes loss of cell viability and elevated oxidative stress via an ASK-1/JNK-dependent mechanism.
We hypothesize that similar interactions occur as a result of ethanol induction of CYP2E1 and TNFα.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cederbaum, Arthur I.& Yang, Lili& Wang, Xiaodong& Wu, Defeng. 2011. CYP2E1 Sensitizes the Liver to LPS- and TNF α-Induced Toxicity via Elevated Oxidative and Nitrosative Stress and Activation of ASK-1 and JNK Mitogen-Activated Kinases. International Journal of Hepatology،Vol. 2012, no. 2012, pp.1-19.
https://search.emarefa.net/detail/BIM-482629
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cederbaum, Arthur I.…[et al.]. CYP2E1 Sensitizes the Liver to LPS- and TNF α-Induced Toxicity via Elevated Oxidative and Nitrosative Stress and Activation of ASK-1 and JNK Mitogen-Activated Kinases. International Journal of Hepatology No. 2012 (2012), pp.1-19.
https://search.emarefa.net/detail/BIM-482629
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cederbaum, Arthur I.& Yang, Lili& Wang, Xiaodong& Wu, Defeng. CYP2E1 Sensitizes the Liver to LPS- and TNF α-Induced Toxicity via Elevated Oxidative and Nitrosative Stress and Activation of ASK-1 and JNK Mitogen-Activated Kinases. International Journal of Hepatology. 2011. Vol. 2012, no. 2012, pp.1-19.
https://search.emarefa.net/detail/BIM-482629
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-482629
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر