Monocyte Chemoattractant Protein 1 is a Prognostic Marker in ANCA-Associated Small Vessel Vasculitis
المؤلفون المشاركون
Bakoush, Omran
Tencer, Jan
Segelmark, Mårten
Ohlsson, Sophie
Torffvit, Ole
المصدر
العدد
المجلد 2009، العدد 2009 (31 ديسمبر/كانون الأول 2009)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2009-07-05
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
The (anti neutrophil cytoplasmatic autoantibody ANCA), associated small vessel vasculitides (ASVV) are relapsing-remitting inflammatory disorders, involving various organs, such as the kidneys.
(Monocyte chemoattractant protein 1 MCP-1) has been shown to be locally up regulated in glomerulonephritis and recent studies have pointed out MCP-1 as a promising marker of renal inflammation.
Here we measure urinary cytokine levels in different phases of disease, exploring the possible prognostic value of MCP-1, together with (interleukin 6 IL-6), (interleukin 8 IL-8) and (immunoglobulin M IgM).
Methods.
MCP-1, IL-6 and IL-8 were measured using commercially available ELISA kits, whereas IgM in the urine was measured by an in-house ELISA.
Results.
The MCP-1 levels in urine were significantly higher in patients in stable phase of the disease, compared with healthy controls.
Patients in stable phase, with subsequent adverse events; had significantly higher MCP-1 values than patients who did not.
MCP-1 and IgM both tended to be higher in patients relapsing within three months, an observation, however, not reaching statistical significance.
Urinary levels of IL-6 correlated with relapse tendency, and IL-8 was associated with disease outcome.
Conclusions.
Patients with ASVV have raised cytokine levels in the urine compared to healthy controls, even during remission.
Raised MCP-1 levels are associated with poor prognosis and possibly also with relapse tendency.
The association with poor prognosis was stronger for U-MCP-1 than for conventional markers of disease like CRP, BVAS, and ANCA, as well as compared to candidate markers like U-IgM and U-IL-8.
We thus consider U-MCP-1 to have promising potential as a prognostic marker in ASVV.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ohlsson, Sophie& Bakoush, Omran& Tencer, Jan& Torffvit, Ole& Segelmark, Mårten. 2009. Monocyte Chemoattractant Protein 1 is a Prognostic Marker in ANCA-Associated Small Vessel Vasculitis. Mediators of Inflammation،Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-482813
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ohlsson, Sophie…[et al.]. Monocyte Chemoattractant Protein 1 is a Prognostic Marker in ANCA-Associated Small Vessel Vasculitis. Mediators of Inflammation No. 2009 (2009), pp.1-7.
https://search.emarefa.net/detail/BIM-482813
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ohlsson, Sophie& Bakoush, Omran& Tencer, Jan& Torffvit, Ole& Segelmark, Mårten. Monocyte Chemoattractant Protein 1 is a Prognostic Marker in ANCA-Associated Small Vessel Vasculitis. Mediators of Inflammation. 2009. Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-482813
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-482813
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر