Inhibition of NF-κB by Dehydroxymethylepoxyquinomicin Suppresses Invasion and Synergistically Potentiates Temozolomide and γ-Radiation Cytotoxicity in Glioblastoma Cells
المؤلفون المشاركون
Tone, Luiz Gonzaga
de Oliveira, H. F.
Roberto, G. M.
Morales, A. G.
Valera, E. T.
Umezawa, K.
Pezuk, J. A.
Brassesco, María Sol
Scrideli, Carlos Alberto
Delsin, L. E. A.
Rego, E. M.
Carlotti Jr., C. G.
Oliveira, J. C.
المصدر
Chemotherapy Research and Practice
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-02-21
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Despite advances in neurosurgery and aggressive treatment with temozolomide (TMZ) and radiation, the overall survival of patients with glioblastoma (GBM) remains poor.
Vast evidence has indicated that the nuclear factor NF-κB is constitutively activated in cancer cells, playing key roles in growth and survival.
Recently, Dehydroxymethylepoxyquinomicin (DHMEQ) has shown to be a selective NF-κB inhibitor with antiproliferative properties in GBM.
In the present study, the ability of DHMEQ to surmount tumor's invasive nature and therapy resistance were further explored.
Corroborating results showed that DHMEQ impaired cell growth in dose- and time-dependent manners with G2/M arrest when compared with control.
Clonogenicity was also significantly diminished with increased apoptosis, though necrotic cell death was also observed at comparable levels.
Notably, migration and invasion were inhibited accordingly with lowered expression of invasion-related genes.
Moreover, concurrent combination with TMZ synergistically inhibited cell growth in all cell lines, as determined by proliferation and caspase-3 activation assays, though in those that express O6-methylguanine-DNA methyltransferase, the synergistic effects were schedule dependent.
Pretreatment with DHMEQ equally sensitized cells to ionizing radiation.
Taken together, our results strengthen the potential usefulness of DHMEQ in future therapeutic strategies for tumors that do not respond to conventional approaches.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Brassesco, María Sol& Roberto, G. M.& Morales, A. G.& Oliveira, J. C.& Delsin, L. E. A.& Pezuk, J. A.…[et al.]. 2013. Inhibition of NF-κB by Dehydroxymethylepoxyquinomicin Suppresses Invasion and Synergistically Potentiates Temozolomide and γ-Radiation Cytotoxicity in Glioblastoma Cells. Chemotherapy Research and Practice،Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-483493
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Brassesco, María Sol…[et al.]. Inhibition of NF-κB by Dehydroxymethylepoxyquinomicin Suppresses Invasion and Synergistically Potentiates Temozolomide and γ-Radiation Cytotoxicity in Glioblastoma Cells. Chemotherapy Research and Practice No. 2013 (2013), pp.1-16.
https://search.emarefa.net/detail/BIM-483493
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Brassesco, María Sol& Roberto, G. M.& Morales, A. G.& Oliveira, J. C.& Delsin, L. E. A.& Pezuk, J. A.…[et al.]. Inhibition of NF-κB by Dehydroxymethylepoxyquinomicin Suppresses Invasion and Synergistically Potentiates Temozolomide and γ-Radiation Cytotoxicity in Glioblastoma Cells. Chemotherapy Research and Practice. 2013. Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-483493
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-483493
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر