A Comparison of the α235 Selective Positive Allosteric Modulators L-838,417 and TPA023 in Preclinical Models of Inflammatory and Neuropathic Pain
المؤلفون المشاركون
Jinks, John
Mace, Hannah
Ivarsson, Magnus
Richardson, Denise
Ward, Cameron
Edye, Michelle
Gurrell, Rachel
Pitcher, Tom
Young, Kimberly
Rees, Huw
Kinloch, Ross
Nicholson, Janet
McMurray, Gordon
Fish, Rebecca
Bell, Christine
Nickolls, Sarah
Moss, Andrew
Tanimoto-Mori, Sachi
Sweatman, Catherine
المصدر
Advances in Pharmacological Sciences
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-11-28
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
GABAA receptors containing α2/3 subunits are current targets in the battle to develop new pain medications, as they are expressed in the spinal cord where increasing inhibitory drive should result in analgesia.
However, this approach is prone to a range of side effects including sedation, cognitive impairment, and abuse as a consequence of the widespread influence of GABA.
The ability to make subtype selective low-efficacy benzodiazepine compounds, which potentiate the action of GABA at specific α subunits, has the potential to reduce this side effect profile.
In this study, we have investigated the effects of the medium-efficacy positive allosteric modulator (PAM) L-838,417 and the low-efficacy PAM TPA023 in a number of preclinical inflammatory and neuropathic pain models.
We conclude that either the higher level of efficacy at α2/3 or efficacy at α5 is required for compounds to have a significant analgesic effect in a range of models, and, therefore, although the side-effect profile of compounds can be reduced compared to typical benzodiazepines, it is unlikely that it can be completely eliminated.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nickolls, Sarah& Mace, Hannah& Fish, Rebecca& Edye, Michelle& Gurrell, Rachel& Ivarsson, Magnus…[et al.]. 2011. A Comparison of the α235 Selective Positive Allosteric Modulators L-838,417 and TPA023 in Preclinical Models of Inflammatory and Neuropathic Pain. Advances in Pharmacological Sciences،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-484790
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nickolls, Sarah…[et al.]. A Comparison of the α235 Selective Positive Allosteric Modulators L-838,417 and TPA023 in Preclinical Models of Inflammatory and Neuropathic Pain. Advances in Pharmacological Sciences No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-484790
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nickolls, Sarah& Mace, Hannah& Fish, Rebecca& Edye, Michelle& Gurrell, Rachel& Ivarsson, Magnus…[et al.]. A Comparison of the α235 Selective Positive Allosteric Modulators L-838,417 and TPA023 in Preclinical Models of Inflammatory and Neuropathic Pain. Advances in Pharmacological Sciences. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-484790
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-484790
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر