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Preparation of Naringeninβ-Cyclodextrin Complex and Its More Potent Alleviative Effect on Choroidal Neovascularization in Rats
المؤلفون المشاركون
Ding, Shu-hua
Shao, Yan
Yang, Xue-wen
Yu, Hai-tao
Xu, Xin-rong
Hang, Li
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-27
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Choroidal neovascularization (CNV) is characterized by abnormal blood vessels growing from the choroid.
Current remedies for CNV have not shown favorable therapeutic efficacy.
It is urgent to identify and develop more safe and potent anti-CNV agents via multiple technologies.
We previously showed that the natural product naringenin attenuated CNV.
However, naringenin has poor water solubility and low bioavailability.
Here, we prepared the β-cyclodextrin (β-CD) complex of naringenin and characterized it using infrared spectra and X-ray diffraction analyses.
Determination of content and solubility in the complex showed that naringenin accounted for 20.53% in the complex and its solubility was increased by more than 10-fold.
Using a laser-induced CNV model in rats we demonstrated that naringenin/β-CD complex more significantly reduced CNV area than naringenin alone in rats.
Furthermore, naringenin and its β-CD complex significantly inhibited the mRNA and protein expression of VEGF, COX-2, PI3K, p38MAPK, MMP-2, and MMP-9 in retina and choroid tissues.
Naringenin/β-CD complex showed more significant inhibitory effect on VEGF and COX-2 expression than naringenin.
These results collectively indicated that naringenin/β-CD complex could be a promising therapeutic option for CNV and that the beneficial effects could be linked to the anti-inflammatory properties of naringenin.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xu, Xin-rong& Yu, Hai-tao& Hang, Li& Shao, Yan& Ding, Shu-hua& Yang, Xue-wen. 2014. Preparation of Naringeninβ-Cyclodextrin Complex and Its More Potent Alleviative Effect on Choroidal Neovascularization in Rats. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-485961
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xu, Xin-rong…[et al.]. Preparation of Naringeninβ-Cyclodextrin Complex and Its More Potent Alleviative Effect on Choroidal Neovascularization in Rats. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-485961
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xu, Xin-rong& Yu, Hai-tao& Hang, Li& Shao, Yan& Ding, Shu-hua& Yang, Xue-wen. Preparation of Naringeninβ-Cyclodextrin Complex and Its More Potent Alleviative Effect on Choroidal Neovascularization in Rats. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-485961
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-485961
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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