Synergistic Action of Flavonoids, Baicalein, and Daidzein in Estrogenic and Neuroprotective Effects : A Development of Potential Health Products and Therapeutic Drugs against Alzheimer’s Disease
المؤلفون المشاركون
Choi, Roy Chi-Yan
Yung, Amanda W. Y.
Guo, Ava J. Y.
Lee, Pinky S. C.
Dong, Tina Ting-Xia
Tsim, Karl Wah-Keung
Zhu, Kevin Y.
Xu, Sherry Li
Zhu, Judy T. T.
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-08-24
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Despite the classical hormonal effect, estrogen has been reported to mediate neuroprotection in the brain, which leads to the searching of estrogen-like substances for treating neurodegenerative diseases.
Flavonoids, a group of natural compounds, are well known to possess estrogenic effects and used to substitute estrogen, that is, phytoestrogen.
Flavonoid serves as one of the potential targets for the development of natural supplements and therapeutic drugs against different diseases.
The neuroprotection activity of flavonoids was chosen for a possible development of anti-Alzheimer's drugs or food supplements.
The estrogenic activity of two flavonoids, baicalein and daidzein, were demonstrated by their strong abilities in stimulating estrogen receptor phosphorylation and transcriptional activation of estrogen responsive element in MCF-7 breast cells.
The neuroprotection effects of flavonoids against β-amyloid (Aβ) were revealed by their inhibition effects on in vitro Aβ aggregation and Aβ-induced cytotoxicity in PC12 neuronal cells.
More importantly, the estrogenic and neuroprotective activities of individual flavonoid could be further enhanced by the cotreatment in the cultures.
Taken together, this synergistic effect of baicalein and daidzein might serve as a method to improve the therapeutic efficacy of different flavonoids against Aβ, which might be crucial in developing those flavonoidsin treating Alzheimer's disease in the future.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Choi, Roy Chi-Yan& Zhu, Judy T. T.& Yung, Amanda W. Y.& Lee, Pinky S. C.& Xu, Sherry Li& Guo, Ava J. Y.…[et al.]. 2013. Synergistic Action of Flavonoids, Baicalein, and Daidzein in Estrogenic and Neuroprotective Effects : A Development of Potential Health Products and Therapeutic Drugs against Alzheimer’s Disease. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-486979
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Choi, Roy Chi-Yan…[et al.]. Synergistic Action of Flavonoids, Baicalein, and Daidzein in Estrogenic and Neuroprotective Effects : A Development of Potential Health Products and Therapeutic Drugs against Alzheimer’s Disease. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-486979
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Choi, Roy Chi-Yan& Zhu, Judy T. T.& Yung, Amanda W. Y.& Lee, Pinky S. C.& Xu, Sherry Li& Guo, Ava J. Y.…[et al.]. Synergistic Action of Flavonoids, Baicalein, and Daidzein in Estrogenic and Neuroprotective Effects : A Development of Potential Health Products and Therapeutic Drugs against Alzheimer’s Disease. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-486979
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-486979
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر