Detection of Canonical Hedgehog Signaling in Breast Cancer by 131-Iodine-Labeled Derivatives of the Sonic Hedgehog Protein
المؤلفون المشاركون
Woodward, Wendy
Sims-Mourtada, Jennifer
Smith, Daniel
Tsao, Ning
Yang, David J.
Opdenaker, Lynn
Tworowska, Izabela
Mourtada, Firas
Larson, Richard
المصدر
Journal of Biomedicine and Biotechnology
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-06-28
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Activation of hedgehog (HH) pathway signaling is observed in many tumors.
Due to a feedback loop, the HH receptor Patched (PTCH-1) is overexpressed in tumors with activated HH signaling.
Therefore, we sought to radiolabel the PTCH-1 ligand sonic (SHH) for detection of cancer cells with canonical HH activity.
Receptor binding of 131I-SHH was increased in cell lines with high HH pathway activation.
Our findings also show that PTCH-1 receptor expression is decreased upon treatment with HH signaling inhibitors, and receptor binding of 131I-SHH is significantly decreased following treatment with cyclopamine.
In vivo imaging and biodistribution studies revealed significant accumulation of 131I-SHH within tumor tissue as compared to normal organs.
Tumor-to-muscle ratios were approximately 8 : 1 at 5 hours, while tumor to blood and tumor to bone were 2 : 1 and 5 : 1, respectively.
Significant uptake was also observed in liver and gastrointestinal tissue.
These studies show that 131I-SHH is capable of in vivo detection of breast tumors with high HH signaling.
We further demonstrate that the hedgehog receptor PTCH-1 is downregulated upon treatment with hedgehog inhibitors.
Our data suggests that radiolabeled SHH derivatives may provide a method to determine response to SHH-targeted therapies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sims-Mourtada, Jennifer& Yang, David J.& Tworowska, Izabela& Larson, Richard& Smith, Daniel& Tsao, Ning…[et al.]. 2012. Detection of Canonical Hedgehog Signaling in Breast Cancer by 131-Iodine-Labeled Derivatives of the Sonic Hedgehog Protein. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-487348
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sims-Mourtada, Jennifer…[et al.]. Detection of Canonical Hedgehog Signaling in Breast Cancer by 131-Iodine-Labeled Derivatives of the Sonic Hedgehog Protein. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-487348
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sims-Mourtada, Jennifer& Yang, David J.& Tworowska, Izabela& Larson, Richard& Smith, Daniel& Tsao, Ning…[et al.]. Detection of Canonical Hedgehog Signaling in Breast Cancer by 131-Iodine-Labeled Derivatives of the Sonic Hedgehog Protein. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-487348
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-487348
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر