Tumor Spreading to the Contralateral Ovary in Bilateral Ovarian Carcinoma Is a Late Event in Clonal Evolution
المؤلفون المشاركون
Micci, Francesca
Haugom, Lisbeth
Abeler, Vera M.
Trope, Claes G.
Ahlquist, Terje
Lothe, Ragnhild A.
المصدر
العدد
المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2009-09-15
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Cancer of the ovary is bilateral in 25%.
Cytogenetic analysis could determine whether the disease in bilateral cases is metastatic or two separately occurring primary tumors, but karyotypic information comparing the two cancerous ovaries is limited to a single report with 11 informative cases.
We present a series of 32 bilateral ovarian carcinoma cases, analyzed by karyotyping and high-resolution CGH.
Our karyotypic findings showed that spreading to the contralateral ovary had occurred in bilateral ovarian cancer cases and that it was a late event in the clonal evolution of the tumors.
This was confirmed by the large number of similar changes detected by HR-CGH in the different lesions from the same patient.
The chromosomal bands most frequently involved in structural rearrangements were 19p13 (n=12) and 19q13 (n=11).
The chromosomal bands most frequently gained by both tumorous ovaries were 5p14 (70%), 8q23-24 (65%), 1q23-24 (57%), and 12p12 (48%), whereas the most frequently lost bands were 17p11 (78%), 17p13 (74%), 17p12 (70%), 22q13 (61%), 8p21 and 19q13 (52%), and 8p22-23 (48%).
This is the first time that 5p14 is seen gained at such a high frequency in cancer of the ovary; possibly oncogene(s) involved in bilateral ovarian carcinogenesis or tumor progression may reside in this band.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Micci, Francesca& Haugom, Lisbeth& Ahlquist, Terje& Abeler, Vera M.& Trope, Claes G.& Lothe, Ragnhild A.. 2009. Tumor Spreading to the Contralateral Ovary in Bilateral Ovarian Carcinoma Is a Late Event in Clonal Evolution. Journal of Oncology،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-487853
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Micci, Francesca…[et al.]. Tumor Spreading to the Contralateral Ovary in Bilateral Ovarian Carcinoma Is a Late Event in Clonal Evolution. Journal of Oncology No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-487853
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Micci, Francesca& Haugom, Lisbeth& Ahlquist, Terje& Abeler, Vera M.& Trope, Claes G.& Lothe, Ragnhild A.. Tumor Spreading to the Contralateral Ovary in Bilateral Ovarian Carcinoma Is a Late Event in Clonal Evolution. Journal of Oncology. 2009. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-487853
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-487853
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر